Effect of Exercise and Weight Loss on Cardiovascular Health
运动和减肥对心血管健康的影响
基本信息
- 批准号:8675909
- 负责人:
- 金额:$ 71.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-01 至 2016-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAdultAdvisory CommitteesBariatricsBehaviorBehavioralBiological MarkersBloodBlood PressureBlood VesselsBody CompositionBody WeightBody Weight ChangesBody Weight decreasedC-reactive proteinCardiacCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemClinicalConsensusCoronary heart diseaseCoupledDataDevelopmentDietDisease OutcomeDoseEnergy IntakeExerciseFutureGlucoseGuidelinesHealthHeart DiseasesHeart failureIndividualInsulinInterventionInvestigationKnowledgeLeft Ventricular MassLife StyleLinkLipidsLiteratureLungMagnetic Resonance ImagingMeasuresMorbidity - disease rateObesityOperative Surgical ProceduresOutcomeOverweightPhysical activityPhysiologic pulsePopulation StudyPreventionPublic HealthRandomizedRecommendationReportingResearchResearch PersonnelRiskRisk FactorsStrokeTumor Necrosis Factor-alphaUnited StatesVascular DiseasesWeightabdominal fatadiponectinbariatric surgerycardiovascular disorder riskcomparison groupdietary restrictiondisorder riskevidence basefitnessgroup interventionimprovedinflammatory markerinterestmortalitynutritionprimary outcomeprogramssecondary outcometherapeutic targetweight loss intervention
项目摘要
DESCRIPTION (provided by applicant): The primary aim of this study is to examine the effect of the consensus public health recommended level of physical activity [moderate physical activity (MOD-PA) = 150 min/wk] versus a higher dose of physical activity [high physical activity (HIGH-PA) = 250 min/wk] in the context of a comprehensive behavioral weight loss program that a includes a reduction in energy intake measures of cardiovascular function using cardiac MRI and biomarkers of vascular disease risk. Each of these exercise doses will be compared independently to a Diet Only group intervention on the proposed primary and secondary outcomes, with MOD-PA also compared to HIGH-PA. This study involves the recruitment of 390 overweight and obese adults who will be randomly assigned to one of the above conditions (Diet Only, MOD-PA, HIGH-PA) for a period of 12 months. Assessment of the primary and secondary outcomes will occur at baseline prior to participation in the intervention, following the initial six months of the intervention, and at the conclusion of 12 months of the intervention. The primary outcome is LVM measured by cardiac MRI. Secondary outcomes include additional cardiac MRI measures (aortic pulse wave velocity, end diastolic volume, aortic distensibility), inflammatory markers (CRP and TNF1) and selected adipocytokines (adiponectin) as biomarkers of risk related to vascular outcomes, body weight, body composition, and cardiorespiratory fitness, and traditional CVD risk factors (lipids, glucose, insulin, blood pressure). Additional secondary analyses will allow for examination of the effects of physical activity independent of weight change on the primary and secondary outcomes.
描述(申请人提供):本研究的主要目的是检查共识公共卫生推荐的体力活动水平[中等体力活动(MOD-PA)= 150分钟/周]与较高剂量体力活动[高体力活动(HIGH-PA)= 250分钟/周]的效果在一个全面的行为减肥计划的背景下,该计划包括使用心脏MRI和血管疾病风险的生物标志物减少心血管功能的能量摄入措施。这些运动剂量中的每一种都将独立地与仅饮食组干预对拟定的主要和次要结局进行比较,MOD-PA也与HIGH-PA进行比较。这项研究招募了390名超重和肥胖的成年人,他们将被随机分配到上述条件之一(仅饮食,MOD-PA,HIGH-PA),为期12个月。主要和次要结局的评估将在参与干预前的基线、干预前6个月后和干预12个月结束时进行。主要结局是通过心脏MRI测量的左心室质量。次要结局包括额外的心脏MRI测量(主动脉脉搏波速度、舒张末期容积、主动脉扩张性)、炎症标志物(CRP和TNF 1)和选定的脂肪细胞因子(脂联素)作为与血管结局、体重、身体成分和心肺功能相关的风险生物标志物,以及传统的CVD风险因素(血脂、葡萄糖、胰岛素、血压)。额外的次要分析将允许检查身体活动对主要和次要结局的影响,而不依赖于体重变化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John M Jakicic其他文献
027 - Network medicine-based approach to interrogate chondroprotective effects of rehabilitative exercise via circulating extracellular vesicles
- DOI:
10.1016/j.joca.2024.02.038 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Hirotaka Iijima;Kai Wang;Ella D'Amico;Wan-Yee Tang;Renee J. Rogers;John M Jakicic;Fabrisia Ambrosio - 通讯作者:
Fabrisia Ambrosio
Myocardial fibrosis is associated with subsequent death and hospitalization for heart failure in obese adults
- DOI:
10.1186/1532-429x-17-s1-m8 - 发表时间:
2015-02-03 - 期刊:
- 影响因子:
- 作者:
Yaron Fridman;Timothy C Wong;Kayla M Piehler;Karolina M Zareba;James Moon;Martin Ugander;Daniel Messroghli;John M Jakicic;Uma Valeti;Chung-Chou Chang;Sanjeev G Shroff;Christopher A Miller;Matthias Schmitt;Peter Kellman;Javed Butler;Mihai Gheorghiade;Erik B Schelbert - 通讯作者:
Erik B Schelbert
John M Jakicic的其他文献
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{{ truncateString('John M Jakicic', 18)}}的其他基金
Molecular Transducers of Physical Activity Clinical Centers (U01) - Pittsburgh Adult Clinical Center
身体活动分子传感器临床中心 (U01) - 匹兹堡成人临床中心
- 批准号:
9245898 - 财政年份:2016
- 资助金额:
$ 71.97万 - 项目类别:
Molecular Transducers of Physical Activity Clinical Centers (U01) - Pittsburgh Adult Clinical Center
身体活动分子传感器临床中心 (U01) - 匹兹堡成人临床中心
- 批准号:
10265116 - 财政年份:2016
- 资助金额:
$ 71.97万 - 项目类别:
Effect of Exercise and Weight Loss on Cardiovascular Health
运动和减肥对心血管健康的影响
- 批准号:
8183827 - 财政年份:2011
- 资助金额:
$ 71.97万 - 项目类别:
Effect of Exercise and Weight Loss on Cardiovascular Health
运动和减肥对心血管健康的影响
- 批准号:
8324188 - 财政年份:2011
- 资助金额:
$ 71.97万 - 项目类别:
Effect of Exercise and Weight Loss on Cardiovascular Health
运动和减肥对心血管健康的影响
- 批准号:
8851650 - 财政年份:2011
- 资助金额:
$ 71.97万 - 项目类别:
Effect of Exercise and Weight Loss on Cardiovascular Health
运动和减肥对心血管健康的影响
- 批准号:
8473269 - 财政年份:2011
- 资助金额:
$ 71.97万 - 项目类别:
Enhanced Behavioral Intervention to Improve Long-Term Weight Loss in Young Adults
加强行为干预以改善年轻人的长期减肥效果
- 批准号:
7706688 - 财政年份:2009
- 资助金额:
$ 71.97万 - 项目类别:
The Effect of a Stepped-Care Approach to Long-Term Weight Loss
阶梯式护理方法对长期减肥的效果
- 批准号:
7680030 - 财政年份:2007
- 资助金额:
$ 71.97万 - 项目类别:
The Effect of a Stepped-Care Approach to Long-Term Weight Loss
阶梯式护理方法对长期减肥的效果
- 批准号:
7317954 - 财政年份:2007
- 资助金额:
$ 71.97万 - 项目类别:
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