Development of Novel Ion Selective Biosensors

从理解大脑的生理和病理(如癫痫、脑癌)到人体性能监测(如可穿戴设备)，对微型离子传感器的应用非常需要。该项目的目的是开发基于具有离子选择膜功能的晶体管的这种传感器。我们将致力于了解这些设备的物理原理，并在灵敏度、稳定性和响应时间方面推动它们达到性能极限。然后，我们将使用合适的神经紊乱模型来验证它们在植入性设备中的使用。

There is a great need for miniaturised ion sensors for applications ranging from understanding physiology and pathology of the brain (e.g. in epilepsy, brain cancer) to human performance monitoring (e.g. with wearables). The aim of this project is to develop such sensors based on transistors functionalised with ion selective membranes. We will aim to understand the physics of these devices and push them to their performance limits in terms of sensitivity, stability and response time. We will then validate their use in implantable devices using suitable model of neurological disorders.