J.P.Kennedy Mental Retardation and Developmental Disabilities Center

描述(由申请人提供)：芝加哥大学智力障碍和发育障碍研究中心(MRDDRC)设在约瑟夫·P·肯尼迪智力障碍研究中心。MRDDRC已被指定为大学范围内的研究所，扩大了芝加哥大学科学家的社区，他们致力于大脑和行为发育研究，以及对患有导致智力低下和残疾的个人的诊断和治疗。为此，MRDDRC包括来自芝加哥大学和其他芝加哥机构的47名研究人员，他们接受了联邦政府对80多个项目的支持。该MRDDRC的目标是通过结合生物医学和行为科学的一系列研究方法，促进智力低下和发育障碍的诊断、预防、治疗和改善。申请者的具体目标是1)扩大MRDD的研究基础，2)促进多学科方法和加强合作，3)通过提供具有成本效益的创新核心设施来提高中心研究人员的生产率，4)促进MRDD研究方面的教育、培训和交流，5)促进互动，并与芝加哥大学以外表现出对MRDD的坚定承诺的研究人员分享专业知识、方法和患者。这些目标将由行政核心和三个科学核心促进：基因组学和生物信息学核心、模式生物体核心和神经科学核心。J.P.Kennedy MRDDRC的研究范围非常广泛，包括对大脑发育的遗传、生化、细胞、生理和行为研究，以及对特定发育障碍(包括癫痫、自闭症、小脑畸形、神经管缺陷、攻击性/爆炸性障碍、药物成瘾、精神分裂症、双相情感障碍、ADHD、神经生殖疾病和巴顿病)的翻译和临床研究。该中心申请的总体目标是通过核心设施基础设施和跨机构互动，促进芝加哥地区智力障碍和发育障碍研究的质量、深度和翻译相关性。

DESCRIPTION (provided by applicant): The University of Chicago Mental Retardation and Developmental Disabilities Research Center (MRDDRC) is based in the Joseph P. Kennedy Mental Retardation Research Center. The MRDDRC has been designated a University-wide institute, expanding the community of University of Chicago scientists who are committed to brain and behavioral development research and the diagnosis and treatment of individuals with afflictions leading to mental retardation and disabilities. To this end the MRDDRC includes 47 researchers from the University of Chicago and other Chicago institutions who have received federal support for over 80 projects. The objective of this MRDDRC is to advance the diagnosis, prevention, treatment and amelioration of mental retardation and developmental disabilities by incorporating a range of research approaches from the biomedical and behavioral sciences. The specific objectives of this applicant are to 1) expand the research base in MRDD, 2) promote a multidisciplinary approach and enhance collaboration, 3) increase the productivity of Center investigators by providing cost effective, innovative core facilities, 4) foster education, training and communication in MRDD research, and 5) promote interaction and share expertise, approaches and patients with investigators outside the University of Chicago who have demonstrated a strong commitment to MRDD. These objectives will be fostered by the Administrative Core, and three scientific cores: Genomics and Bioinformatics Core, Model Organisms Core and Neuroscience Core. The scope of the J.P. Kennedy MRDDRC research portfolio is remarkably broad, encompassing genetic, biochemical, cellular, physiological and behavioral studies of brain development as well as translational and clinical research on specific developmental disabilities including epilepsy, autism, cerebellar malformations, neural tub defects, aggression/explosive disorder, drug addiction, schizophrenia, bipolar disorder, ADHD, neurogenerative diseases, and Batten's disease. The overarching goal of this Center application is to promote, through core facility infrastructure and trans-institutional interactions, the quality, depth and translational relevance of Chicago-area research into mental retardation and developmental disabilities.