Flightless I, a terget for new wound therapies

创伤、烧伤和烫伤是常见的伤害，可导致畸形、毁容和行动不便。我们已经证明，细胞骨架蛋白，即Flitless I(FliI)，是伤口修复的重要调节因子。我们计划使用新的细胞特异性转基因动物模型进一步研究FliI在创伤和烧伤中的作用，并开发一种基于FliI抗体的新疗法来治疗创伤和烧伤。

Wounds, burns and scalds are frequent injuries which can lead to deformity, disfigurement and loss of movement. We have shown that the cytoskeletal protein, Flightless I (FliI), is an important regulator of wound repair. We plan to further investigate FliI in wound and burn injuries using new cell-specific transgenic animal models and to develop a new FliI-antibody based therapy to treat wound and burn injuries.