Targeted delivery of CBD and other therapeutics for Diffuse Intrinsic Pontine Glioma (DIPG)

Gershkovich和Marlow一直在研究针对中枢神经系统止痛剂大麻二醇的不同方法：(1)口服和脂类制剂；(2)鞘内给药和纳米制剂。我们发现我们可以改变大麻二酚在中枢神经系统中的生物分布。以这些配方和理解为起点，该项目的重大挑战是设计基于脂质的纳米配方，以最大限度地提高药物在脑桥中的浓度，用于治疗弥漫性固有桥脑胶质瘤(DIPG)(一种儿科脑瘤)--发现于脑干的一个区域，称为脑桥。选定的药物将具有与大麻二酚非常不同的物理化学性质，因此该项目还将带来对针对中枢神经系统内不同区域的药物的更高水平的了解。

Gershkovich and Marlow have been working on different approaches to target the analgesic cannabidiol to the CNS (1) oral delivery and lipid based formulations and (2) intrathecal delivery and nanoformulations. We have found that we can alter the cannabidiol biodistribution within the CNS. Using these formulations and understanding as the starting point, the grand challenge of this project is to design lipid based and nanoformulations to maximise the concentrations of drugs in the pons for the treatment of Diffuse Intrinsic Pontine Glioma (DIPG)(a paediatric brain tumour) -found in an area of the brainstem known as the pons. The drugs selected will have very different physicochemical properties to those of cannabidiol and hence the project will also bring a higher level of understanding to targeting drugs to different regions within the CNS.