Physicochemical characterisation of oligonucleotides (RNA, DNA)

虽然寡核苷酸是很有前途的治疗药物，但它们的配方具有挑战性，因为它们在较高浓度下具有相当大的不可预测的粘度，这是注射给药的障碍。使用一系列物理化学分析工具来研究分子间和分子内的相互作用，该项目旨在对寡核苷酸粘度与其物理化学性质的关系有基本的了解，并将这些知识应用于控制寡核苷酸配方粘度，使这些有希望的化合物能够作为注射药物输送。

While oligonucleotides are promising therapeutics, their formulation is challenging because of their considerable and unpredictable viscosity at higher concentrations which is an obstacle to delivery by injection. Using a range of physicochemical analysis tools to study inter- and intramolecular interactions, this project aims to generate fundamental understanding of how oligonucleotide viscosity is related to their physicochemical properties and apply this knowledge to control oligonucleotide formulation viscosity, enabling delivery of these promising compounds as injectable medicines.