AGING AND CANCER PROGRAM

描述：(申请人描述)我们建议在威斯康星大学麦迪逊综合癌症中心(UWCCC)内建立“老龄化与癌症计划”。我们在这方面具有得天独厚的优势，因为这一应用程序建立在一个大型、不断增长和多样化的老龄化研究项目提供的坚实基础上，该项目将与UWCCC的研究人员和资源进行富有成效的互动。关于老龄化的社会学、心理学、健康服务和生物医学方面的研究一直在威斯康星大学麦迪逊分校进行，并正在大力扩大，令人印象深刻的NIA赠款支持组合证明了这一点。这些研究非常多样化，包括NIA对三个计划项目的支持：两个大型、长期、纵向的基于人群的研究(“威斯康星州纵向研究”和“健康与疾病的综合途径-MIDUS”)和“恒河猴饮食限制”。老龄化研究也得到了强大的单位的支持，包括威斯康星州大学的老龄研究所、医学部的老年医学和老年学部门以及退伍军人管理局GRECC。其他重要的支持来自NIH资助的其他中心，包括心身交互研究(NIMH)、健康与老龄化人口统计学(NIA)和威斯康星州跨学科分子成像中心(NCI)。UW老龄社区和UWCCC之间现有的联系，虽然不是完全没有，但在很大程度上是生物医学的。然而，我们在衰老和癌症方面拥有强大的科学实力，以至于我们处于最有利的地位，能够在这两个领域之间创造和建立协同效应。此外，过去阻碍这种合作的障碍已不复存在，并承诺为建立这一新计划提供重大的机构支持。因此，在长期研究啮齿动物模型中自发性晚年癌症的老年学家理查德·温德鲁奇博士的领导下，我们成立了一个由癌症生物学家、老年病学家、肿瘤学家、老年病学家和人口科学家组成的小组，以解决五个主题领域：护理模式(Maureen Smith，MD，PhD，公共卫生硕士[领导者]，Gary Shapiro，MD[共同领导者])；共病的影响(Sanjay Asthan，MD，James Stewart，MD)；心理社会问题(Susan Heidrich，PhD，Carol Ryff，PhD)；姑息护理(James Cleary，MD，Elizabeth Kramer，PhD)；和衰老与癌症生物学(Richard Weindruch博士、David Jarrard医学博士)。我们认为，鉴于人口统计现实和解决关键知识差距的机会，创建该计划及其将培育的研究是至关重要的。

DESCRIPTION: (Applicant's Description) We propose to establish the "Aging and Cancer Program" within the University of Wisconsin-Madison Comprehensive Cancer Center (UWCCC). We are uniquely positioned to do so as this application rests on the strong foundation provided by a large, growing and diverse aging research program that will interact productively with the investigators and resources of the UWCCC. Studies on sociological, psychological, health services and biomedical aspects of aging have long been pursued at the UW-Madison and are vigorously expanding as evidenced by an impressive portfolio of NIA grant support. These studies are incredibly diverse and include NIA support for three Program Projects: two large, long-term, longitudinal population-based studies ("Wisconsin Longitudinal Study" and "Integrative Pathways to Health and Illness- MIDUS"), and "Dietary Restriction in Rhesus Monkeys". Aging research is also supported by strong units including the UW's Institute on Aging, the Department of Medicine's Section of Geriatrics and Gerontology, and the VA GRECC. Additional important support is derived from other NIH-funded Centers including those for the Study of Mind-Body Interaction (NIMH) and Demography of Health and Aging (NIA) and the Wisconsin Interdisciplinary Molecular Imaging Center (NCI). The existing links between the UW aging community and the UWCCC, while not entirely absent, are largely biomedical. However, we have powerful scientific strengths in both aging and cancer such that we could not be better positioned to create and build synergies between these two areas. Further, past barriers to such collaboration no longer exist and significant institutional support for building this new program has been committed. Accordingly, under the leadership of Richard Weindruch, Ph.D., a gerontologist who has long investigated spontaneous late-life cancers in rodent models, we have formed a group of cancer biologists, gerontologists, oncologists, geriatricians and population scientists to address five thematic areas: Patterns of Care (Maureen Smith, MD, PhD, MPH [Leader], Gary Shapiro, MD [Co-Leader]); Effects of Comorbidity (Sanjay Asthana, MD, James Stewart, MD); Psychosocial Issues (Susan Heidrich, PhD, Carol Ryff, PhD); Palliative Care (James Cleary, MD, Elizabeth Kramer, PhD); and Biology of Aging and Cancer (Richard Weindruch, PhD, David Jarrard, MD). We view the creation of this Program and the research it will nurture to be vital in view of demographic realities and opportunities to address critical knowledge gaps.