SPORE in Lung Cancer

描述(由申请者提供)：本申请在达纳·法伯/哈佛癌症中心内创建了哈佛大学肺癌卓越研究(孢子)专业项目。Dana-Farber/哈佛癌症中心肺癌孢子研究包括来自波士顿所有哈佛附属医院、哈佛医学院和哈佛公共卫生学院的研究人员。肺癌中的这一孢子将建立在DF/HCC内现有的正在进行的研究的基础上。五个主要项目得到支持：项目1将评估男性和女性对肺腺癌遗传易感性的影响及其与烟草烟雾暴露的相互作用。项目2将分析肺癌中C/EBPα的失调，其下游靶点，以及它对肺癌患者预后的潜在影响。项目3将把阵列技术应用于研究人类肺癌及其与小鼠模型的关系。项目4将研究CDK2抑制剂在体外和体内的作用，并将这些发现应用于肺癌患者的人体试验。项目4将研究血管内皮生长因子受体抑制剂和体内化疗的作用，并将这些发现应用于肺癌患者的人体试验。这些项目通过建立4个核心来整合。这些核心包括1)组织和病理学核心，2)管理、评估和规划核心，3)生物统计学核心，4)基因组学核心。这份孢子申请概述了一个发展项目计划，其中包括我们选择新项目的计划，并包括七个提交的可能得到支持的提案。职业发展奖计划概述了识别和支持肺癌领域有才华的年轻研究人员的机制。发展项目和职业发展奖励计划将为社区参与DF/HCC肺癌孢子的规划和财务支持提供重点。DF/HCC肺癌孢子的目标是将生物和技术进步转化为对肺癌患者和肺癌高危人群具有临床意义的进步。

DESCRIPTION (provided by applicant): This application creates a Specialized Program in Research Excellence (SPORE) in Lung Cancer at Harvard University within the Dana Farber/Harvard Cancer Center. The Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer includes investigators from all Harvard-affiliated hospitals in Boston, Harvard Medical School, and the Harvard School of Public Health. This SPORE in Lung Cancer will build on the strengths of established ongoing investigation within the DF/HCC. Five major projects are supported: Project 1 will assess the impact of inherited susceptibility to adenocarcinoma of the lung in men and women and its interaction with exposures to tobacco smoke. Project 2 will analyze the dysregulation of C/EBP alpha in lung cancer, its downstream targets, and its potential impact on the outcome of lung cancer patients. Project 3 will apply array technology to the study of human lung cancer and its relationship to murine models. Project 4 will investigate the role of cdk2 inhibitors in vitro, in vivo, and apply these finding to human trials for patients with lung cancer. Project 4 will study the role of vascular endothelial growth factor receptor inhibitors and chemotherapy in vivo, and apply these finding to human trials for patients with lung cancer. These Projects are integrated by the establishment of 4 cores. These include 1) Tissue and Pathology Core, 2) Administration, Assessment and Planning Core, 3) Biostatistics Core, 4) Genomics Core. This SPORE application outlines a Developmental Projects Program that includes our plan for selection of new projects and includes seven submitted proposals that could be supported. The Career Developmental Award Program outlines the mechanism for the identification and support of talented young investigators in lung cancer. The Developmental Projects and Career Development Award Program will provide the focus for involvement of the community in planning and financial support of the DF/HCC Lung Cancer SPORE. The goal of the DF/HCC Lung Cancer SPORE is the translation of biological and technological advances into clinically meaningful advances for patients with lung cancer and subjects at risk for lung cancer.