BIOINFORMATICS/BIOSTATISTICS CORE

生物信息学/生物统计学核心的目标是解决生物信息学、统计学和数据 参与SPORE项目的管理需求。为此，生物信息学/生物统计学核心 将与现有的耶鲁信息学资源，项目和研究小组密切合作。的 核心也与孢子标本资源核心紧密结合，用于组织的开发 跟踪和注释系统。生物信息学/生物统计学核心的具体目标是：1） SPORE项目数据的生物信息学和统计分析; 2）设计、建造和维护 SPORE数据管理和分析系统（SPORE-DMAS）。对于1），一个重要的焦点是 在整个SPORE项目期间与项目调查人员密切互动。核心 将提供持续的分析服务，如方案设计，数据注释和可视化。的 分析将主要集中在项目1、2和4，这些项目涉及阐明早期风险因素， 在转移性黑色素瘤细胞中检测预测性表观基因组标志物，以及 建立黑色素瘤患者的血清学特征。对于2），核心将设计，建造和 维护一个孢子数据管理和分析系统（孢子-DMAS），用于跟踪生物 标本以及临床和实验数据的处理。SPORE-DMAS将紧密集成 整合成SPORE标本资源核心，并将处理SPORE项目的数据管理需求 成员SPORE-DMAS将广泛利用耶鲁大学现有的信息学系统， 以及来自caBIG组织库和病理学工具工作区的资源。核心也将是 涉及根据SPORE数据和资源共享计划提供数据。

The goal of the bioinformatics/biostatistics core is to address the bioinformatics, statistical and data management needs of the participating SPORE projects. To this end, the bioinformatics/biostatistics core will work in close collaboration with existing Yale informatics resources, projects and research groups. The core is also tightly integrated with the SPORE specimen resource core for the development of a tissue tracking and annotation system. The specific aims of the bioinformatics/biostatistics core are 1) the bioinformatics and statistical analysis of SPORE project data and 2) the design, building and maintenance of a SPORE data management and analysis system (SPORE-DMAS). For 1), an important focus is the close interaction with the project investigators during the entire duration of the SPORE program. The core will provide continuous analysis services such as protocol design, data annotation and visualization. The analyses will chiefly focus on projects 1,2 and 4, which concern the elucidation of risk factors for early onset BCC patients, the detection of predictive epigenomic markers in metastatic melanoma cells, as well as establishing the serological profiles of melanoma patients. For 2), the core will design, build and maintain a SPORE data management and analysis system (SPORE-DMAS) for tracking of biological specimens, and processing of clinical and experimental data. The SPORE-DMAS will be tightly integrated into SPORE specimen resource core, and will handle the data management needs of the SPORE project members. The SPORE-DMAS will make extensive use of existing informatics systems at Yale University, and of resources from caBIG's Tissue Banks and Pathology Tools Workspace. The core will also be concerned with making data available according to the SPORE data and resource sharing plan.