PILOT 1-EFFECTS OF EXERCISE ON INSULIN SENSITIVITY AND METABOLIC SYNDROME

描述（由申请人提供）： Charles R.医学和科学（德鲁）德鲁大学建议继续并通过专门的“糖尿病和代谢城市研究和教育中心”（CUREDM）加强其临床卓越研究中心（CCRE）的活动。指导该中心活动的目的是增加从事临床研究的研究科学家的临界质量，并增加在德鲁进行的糖尿病和代谢相关临床研究的数量。糖尿病是《2010年健康人》的重点领域之一，这是国家健康议程的蓝图。此外，德鲁大学独特的患者群体-包括约54%的西班牙裔，34%的非洲裔美国人，7%的非西班牙裔白色，5%的亚裔美国人-患有糖尿病和代谢相关疾病的比例不成比例。为此，德鲁建议支持四名致力于在糖尿病领域建立临床研究事业的初级研究人员，并在每个资源核心中配备一名新兴科学家。该中心将由一名新的主要研究者（PI）领导，PI是一名具有独立研究支持的成熟研究者，可以为研究糖尿病和代谢相关疾病的研究者提供高水平的指导。 这项申请的具体目标是： 1.增加糖尿病及代谢相关临床研究人员的临界质量; 2.通过支持导师制研究试点项目，将敬业的高级研究人员与有前途的初级教师配对，促进教师发展;通过提供一个有利于科学发现和短期课程和/或德鲁大学正式学位培训的环境，提高初级研究人员的职业生涯; 4.通过两个创新的研究核心，在严格的临床研究方法的背景下改善糖尿病和代谢紊乱患者的预后：1）转化研究核心，将与德鲁的研究密集型合作伙伴加州大学洛杉矶分校合作; 2）身体成分和代谢核心;和5。增加知识和研究活动（赠款提交和采购、演讲和出版物），特别是在糖尿病和代谢紊乱方面，因为它们与改善妇女、少数民族/种族和其他弱势群体的保健有关。

DESCRIPTION (provided by applicant): Charles R. Drew University of Medicine and Science (Drew) proposes to continue and enhance its Clinical Center for Research Excellence (CCRE) activities through the specialized "Center of Urban Research and Education in Diabetes and Metabolism" (CUREDM). The purposes guiding the center's activities are to increase the critical mass of research scientists engaged in clinical research and to increase the number of diabetes and metabolic-related clinical research conducted at Drew. Diabetes is one of the key focus areas of Healthy People 2010, the blueprint for the nation's health agenda. In addition, the unique patient population at Drew University-comprised of approximately 54 percent Hispanic, 34 percent African American, 7 percent non-Hispanic white, and 5 percent Asian American-suffers disproportionately from diabetes and metabolic related disorders. To this end, Drew proposes to support four junior investigators committed to establishing a clinical research career in the area of diabetes and to staff an emerging scientist in each of the resource cores. The center will be under the direction of a new principal investigator (PI) who is an established investigator with independent research support and who can provide a high level of mentoring for investigators studying diabetes and metabolic-related diseases. The specific aims for this application are: 1. To increase the critical mass of diabetes and metabolic-related clinical researchers; 2. To promote faculty development through the support of mentored-research pilot projects by pairing dedicated senior investigators with promising junior faculty; 3. To enhance the careers of junior investigators by providing an environment that facilitates scientific discovery and short-term curricula and/or formal degree training at Drew University; 4. To improve diabetes and metabolic disorder patient outcomes in the context of methodologically rigorous clinical research through two innovative research cores: 1) The Translational Research Core, which will collaborate with Drew's research-intensive partner, UCLA; and 2) the Body Composition and Metabolism Core; and 5. To increase the body of knowledge and research activity (grant submissions and procurement, presentations, and publications), especially in diabetes and metabolic disorders as they relate to improving the health care of women, ethnic/racial minorities, and other disadvantaged populations.