CLINICAL TRIAL: DANCE DANCE REVOLUTION (DDR)

临床试验：舞蹈革命 (DDR)

基本信息

批准号：
8173592
负责人：
Stanley Hsia
金额：
$ 4.18万
依托单位：
CHARLES R. DREW UNIVERSITY OF MED & SCI
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2011-06-30
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An estimated 21 million people in the United States are affected by type 2 diabetes mellitus 1. In the U.S., ethnic minority groups like those served by our institution are disproportionately affected by obesity and type 2 diabetes 2, 3. Despite the wide array of pharmacological treatments now available, roughly half of all diabetic patients nationwide still have a hemoglobin A1c (HbA1c) level above 7% 4. The ADA recommends that all diabetic patients engage regularly in a minimum of 150 minutes per week of moderate-intensity aerobic activity 5. Sustained exercise trainingimproves glucose uptake and glycemic control 6, 7 in a dose-dependent and rapid fashion, demonstrable within as little as 12 hours after a single bout of intense exercise 8. However, it is also relatively transient if the exercise stimulus is not maintained, with a loss of insulin sensitization within ~72 hours after abrupt cessation of an exercise program 9, 10. The improvement in insulin sensitivity can be reproducibly demonstrated even in the absence of changes in body weight or adiposity, as shown in shorter-duration studies 11, 12. Chronic maintenance of regular physical activity not only contributes to weight loss and reduced adiposity, but also improves multiple cardiovascular risk factors 13-18, cardiovascular and overall mortality 19-24, a number of nonmetabolic \conditions 25-31, and psychosocial traits 32-35. Exercise prescriptions can be customized to suit a patient's unique preferences and lifestyle, which leads to improved long-term compliance 36. Direct costs associated with self-initiated physical activity programs may also be favorable compared to other therapies. Specific Aim #1: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in glycemic control in adult patients with type 2 diabetes mellitus. Specific Aim #2: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in body composition, aerobic fitness, cardiovascular risk factors, attendance and sustainability of physical activity, and psychological correlates of exercise behavior, in adult patients with type 2 diabetes mellitus.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。估计在美国，估计有2100万人受到2型糖尿病的影响。在美国，像我们机构所服务的少数群体受到肥胖症和2型糖尿病2、3的影响不成比例的影响。尽管有一系列药理治疗，但现在有大量的全国性糖尿病患者，在全国范围内大约有一半的糖尿病患者。建议所有糖尿病患者定期定期进行中等强度的有氧运动活性至少150分钟。5。持续的运动训练训练模拟葡萄糖的吸收和血糖控制6、7在剂量依赖和快速方面，在剂量依赖和快速的时尚中，在一次性锻炼8之后，它也不是在固定的情况下进行的，如果在启动中，它也不是在施加的效率上。〜72小时突然停止锻炼计划9，10。胰岛素敏感性的提高即使在缺乏体重或肥胖的情况下，也可以证明胰岛素敏感性的改善，如短期内的研究11，12。长期维持慢性的体育锻炼，不仅会导致体重损失，而且还可以改善肥胖和高度的次数，而且还可以改善多个心脏的危险，并提高了多个心脏的危险。非代谢\条件25-31和社会心理特征32-35。可以定制锻炼处方以适合患者的独特偏好和生活方式，从而改善了长期依从性36。与其他疗法相比，与自我启动的体育活动计划相关的直接成本也可能是有利的。具体目的＃1：比较自我启动的exerergaming与自我发射的跑步机运动对2型糖尿病患者血糖控制变化的变化的影响。具体目的2：比较自我启动的经埃马抗动物与自我发射的跑步机运动对身体成分的变化，有氧健身，心血管危险因素，体育锻炼的出勤率和可持续性以及运动行为的心理相关性以及2型2型糖尿病患者的心理相关性的影响 Mellitus。