CLINICAL TRIAL: DANCE DANCE REVOLUTION (DDR)

临床试验：舞蹈革命 (DDR)

• 批准号: 8173592
• 负责人: Stanley Hsia
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173592
• 关键词: Adult; Aerobic; Aerobic Exercise; Affect; Behavior; Body Composition; Body Weight; Body Weight decreased; Cardiovascular system; Chronic; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Dancing; Direct Costs; Dose; Exercise; Funding; Glycosylated hemoglobin A; Grant; Hour; Institution; Insulin; Life Style; Maintenance; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Pharmacological Treatment; Physical activity; Research; Research Personnel; Resources; Source; Stimulus; United States; United States National Institutes of Health; cardiovascular risk factor; diabetic patient; ethnic minority population; fitness; glucose uptake; glycemic control; improved; insulin sensitivity; mortality; preference; programs; psychologic; psychosocial; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An estimated 21 million people in the United States are affected by type 2 diabetes mellitus 1. In the U.S., ethnic minority groups like those served by our institution are disproportionately affected by obesity and type 2 diabetes 2, 3. Despite the wide array of pharmacological treatments now available, roughly half of all diabetic patients nationwide still have a hemoglobin A1c (HbA1c) level above 7% 4. The ADA recommends that all diabetic patients engage regularly in a minimum of 150 minutes per week of moderate-intensity aerobic activity 5. Sustained exercise trainingimproves glucose uptake and glycemic control 6, 7 in a dose-dependent and rapid fashion, demonstrable within as little as 12 hours after a single bout of intense exercise 8. However, it is also relatively transient if the exercise stimulus is not maintained, with a loss of insulin sensitization within ~72 hours after abrupt cessation of an exercise program 9, 10. The improvement in insulin sensitivity can be reproducibly demonstrated even in the absence of changes in body weight or adiposity, as shown in shorter-duration studies 11, 12. Chronic maintenance of regular physical activity not only contributes to weight loss and reduced adiposity, but also improves multiple cardiovascular risk factors 13-18, cardiovascular and overall mortality 19-24, a number of nonmetabolic \conditions 25-31, and psychosocial traits 32-35. Exercise prescriptions can be customized to suit a patient's unique preferences and lifestyle, which leads to improved long-term compliance 36. Direct costs associated with self-initiated physical activity programs may also be favorable compared to other therapies. Specific Aim #1: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in glycemic control in adult patients with type 2 diabetes mellitus. Specific Aim #2: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in body composition, aerobic fitness, cardiovascular risk factors, attendance and sustainability of physical activity, and psychological correlates of exercise behavior, in adult patients with type 2 diabetes mellitus.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 据估计，美国有 2100 万人受到 2 型糖尿病的影响 1。在美国，像我们机构服务的少数族裔群体受到肥胖和 2 型糖尿病的影响尤为严重 2, 3。尽管现在有多种药物治疗方法，但全国大约一半的糖尿病患者的糖化血红蛋白 (HbA1c) 水平仍然高于 7% 4。 ADA 建议所有糖尿病患者每周定期进行至少 150 分钟的中等强度有氧活动 5. 持续运动训练可改善葡萄糖摄取和血糖控制 6, 7 以剂量依赖性和快速方式，在单次剧烈运动后短短 12 小时内即可显现出来 8. 然而，如果不维持运动刺激，这种效果也是相对短暂的，胰岛素敏感性会在 突然停止锻炼计划后约 72 小时 9, 10。即使在体重或肥胖没有变化的情况下，也可以重复证明胰岛素敏感性的改善，如短期研究所示 11, 12。长期维持规律的体力活动不仅有助于减肥和减少肥胖，而且还可以改善多种心血管危险因素 13-18、心血管和总体死亡率 19-24、一些 非代谢条件 25-31 和心理社会特征 32-35。可以定制运动处方，以适应患者独特的偏好和生活方式，从而提高长期依从性36。与其他疗法相比，与自我发起的身体活动计划相关的直接成本也可能是有利的。 具体目标#1：比较自主运动游戏与自主跑步机运动对成年 2 型糖尿病患者血糖控制变化的影响。 具体目标#2：比较自我发起的运动游戏与自我发起的跑步机运动对成年 2 型糖尿病患者的身体成分变化、有氧适能、心血管危险因素、体力活动的出勤率和可持续性以及运动行为的心理相关性的影响 梅利图斯。