CLINICAL TRIAL: DANCE DANCE REVOLUTION (DDR)

临床试验：舞蹈革命 (DDR)

• 批准号: 8173592
• 负责人: Stanley Hsia
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173592
• 关键词: Adult; Aerobic; Aerobic Exercise; Affect; Behavior; Body Composition; Body Weight; Body Weight decreased; Cardiovascular system; Chronic; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Dancing; Direct Costs; Dose; Exercise; Funding; Glycosylated hemoglobin A; Grant; Hour; Institution; Insulin; Life Style; Maintenance; Minority Groups; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Patients; Pharmacological Treatment; Physical activity; Research; Research Personnel; Resources; Source; Stimulus; United States; United States National Institutes of Health; cardiovascular risk factor; diabetic patient; ethnic minority population; fitness; glucose uptake; glycemic control; improved; insulin sensitivity; mortality; preference; programs; psychologic; psychosocial; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An estimated 21 million people in the United States are affected by type 2 diabetes mellitus 1. In the U.S., ethnic minority groups like those served by our institution are disproportionately affected by obesity and type 2 diabetes 2, 3. Despite the wide array of pharmacological treatments now available, roughly half of all diabetic patients nationwide still have a hemoglobin A1c (HbA1c) level above 7% 4. The ADA recommends that all diabetic patients engage regularly in a minimum of 150 minutes per week of moderate-intensity aerobic activity 5. Sustained exercise trainingimproves glucose uptake and glycemic control 6, 7 in a dose-dependent and rapid fashion, demonstrable within as little as 12 hours after a single bout of intense exercise 8. However, it is also relatively transient if the exercise stimulus is not maintained, with a loss of insulin sensitization within ~72 hours after abrupt cessation of an exercise program 9, 10. The improvement in insulin sensitivity can be reproducibly demonstrated even in the absence of changes in body weight or adiposity, as shown in shorter-duration studies 11, 12. Chronic maintenance of regular physical activity not only contributes to weight loss and reduced adiposity, but also improves multiple cardiovascular risk factors 13-18, cardiovascular and overall mortality 19-24, a number of nonmetabolic \conditions 25-31, and psychosocial traits 32-35. Exercise prescriptions can be customized to suit a patient's unique preferences and lifestyle, which leads to improved long-term compliance 36. Direct costs associated with self-initiated physical activity programs may also be favorable compared to other therapies. Specific Aim #1: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in glycemic control in adult patients with type 2 diabetes mellitus. Specific Aim #2: To compare the effects of self-initiated exergaming versus self-initiated treadmill exercise on changes in body composition, aerobic fitness, cardiovascular risk factors, attendance and sustainability of physical activity, and psychological correlates of exercise behavior, in adult patients with type 2 diabetes mellitus.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据估计，美国有2100万人患有1型糖尿病。在美国，像我们机构服务的那些少数民族群体受到肥胖和2型糖尿病3的影响不成比例。尽管目前有多种药物治疗可用，但全国大约一半的糖尿病患者的血红蛋白A1c(HbA1c)水平仍高于7%4。ADA建议所有糖尿病患者定期进行每周至少150分钟的中等强度有氧运动5。持续的运动训练以一种剂量依赖和快速的方式改善葡萄糖摄取和血糖控制。在一次高强度运动后短短12小时内表现出来8.然而，如果不维持运动刺激，这也是相对短暂的，在突然停止运动计划9、10后约72小时内胰岛素敏感度丧失。即使在体重或肥胖没有变化的情况下，胰岛素敏感度的改善也可以重现，如较短持续时间的研究11、12所示。长期保持有规律的体力活动不仅有助于减肥和减少肥胖，而且还能改善多种心血管风险因素13-18、心血管疾病和总死亡率19-24、一些非代谢条件25-31、和心理社会特征32-35。运动处方可以定制，以适应患者的独特偏好和生活方式，从而改善长期依从性36。与其他疗法相比，与自我发起的体力活动计划相关的直接成本也可能更有利。 具体目标#1：比较自我启动运动和自我启动跑步机运动对成年2型糖尿病患者血糖控制的影响。 具体目标#2：比较自我运动性运动和自我跑步机运动对成年2型糖尿病患者身体成分、有氧健身、心血管危险因素、体力活动的出勤率和持续性以及运动行为的心理相关性的影响。 糖尿病。