Basic and Clinical Research Training in Thrombosis

描述(由申请人提供)： 每年约有200万美国人患上静脉和动脉血栓疾病。以前，学术机构一直是对这些疾病的发病机制和新疗法的见解的来源。随着血液学实习生向肿瘤学和干细胞生物学方向发展的最新趋势，继续发展血栓形成和止血领域未来研究人员的渠道至关重要。这一多学科培训计划的目标是培养一批聪明、年轻的博士后研究员，从事涉及血栓形成或止血障碍的分子发病机制和治疗的独立和最先进的基础和/或临床研究。所有受训人员将接受正常和异常止血生理学的核心指导，包括血小板、凝血因子、纤溶和内皮细胞的作用。作为后续研究的基础，课程和指导将确保理解遗传学、生物化学、细胞生物学、分子生物学、流行病学和统计学的原理。尽管培训将根据学员的兴趣而量身定做，但基于本项目教师的优势，有三个领域将受到特别重视。1)血管血栓形成和出血的动物模型将被用来剖析关键的病理生理机制，测试新的治疗方法，并识别修饰基因。2)剪应力与生物工程。血流和切应力对血栓形成的生理学有重要影响，流变学原理将被研究。已建立的活体显微镜系统、平行平板流动室以及锥体和平板粘度计将用于表征参与血栓形成的分子、GONE调节和信号事件。3)流行病学的临床研究、设计和分析。后一部分将成为未来翻译研究工作的基石。这一计划的一个主要优势是我们的基础(生物工程师、血液学家、遗传学家、生物化学家、细胞生物学家)和临床研究人员(血液学家、临床和遗传流行病学家、统计学家)之间的成功桥梁和合作。将强调卓越的指导，并制定了计划 教授和评估学员的指导能力。最后，制定了招募代表人数不足的少数族裔的综合战略。

DESCRIPTION (provided by applicant): Venous and arterial thrombotic diseases strike about two million Americans each year. Previously, academic institutions have been the source of insights into the pathogenesis and novel therapies for these disorders. With the recent trends of Hematology trainees toward careers in oncology and stem cell biology, it is crucial to continue to develop a pipeline of future investigators in the area of thrombosis and hemostasis. The goal of this multidisciplinary training program is to train a group of bright, young postdoctoral fellows to conduct independent and state-of-the-art basic and/or clinical research involving the molecular pathogenesis and treatment of disorders of thrombosis or hemostasis. All trainees will receive core instruction in the normal and abnormal physiology of hemostasis, including the roles of platelets, coagulation factors, fibrinolysis and endothelial cells. To serve as the basis for the subsequent research studies, coursework and mentoring will ensure an understanding of the principles of genetics, biochemistry, cell biology, molecular biology, epidemiology and statistics. Although the training will be tailored to the trainees interests, based on the strengths of the faculty in this Program, three areas will receive particular emphasis. 1) Animal models of vascular thrombosis and hemorrhage will be used to dissect crucial pathophysiologic mechanisms, to test novel therapies and to identify modifying genes. 2) Shear stress and bioengineering. Blood flow and shear stress have important affects on the physiology of thrombus formation, and the principles of rheology will be studied. Established systems of intravital microscopy, parallel plate flow chambers and cone and plate viscometers will be used to characterize molecules, gone regulation and signaling events participating in thrombus formation. 3) Clinical research in epidemiology, design and analysis. This latter component will be the cornerstone of future translational research efforts. A major strength of this program is the successful bridging and collaborations of our basic (bioengineers, hematologists, geneticists, biochemists, cell biologists) and clinical research faculty (hematologists, clinical and genetic epidemiologists, statisticians). Superior mentorship will be emphasized, and plans are in place to teach and evaluate the mentoring abilities of the trainees. Finally, a comprehensive strategy is in place for recruiting underrepresented minorities.