2023 Basic Mechanisms to Clinical Trials in Brain Tumors Gordon Research Conference

2023年脑肿瘤临床试验的基本机制戈登研究会议

• 批准号: 10751111
• 负责人: SADHAN MAJUMDER
• 金额: $ 1.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-22 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10751111
• 关键词: Adult; Affect; Brain; Brain Neoplasms; Breathing; Caring; Cementation; Childhood; Clinical Investigator; Clinical Trials; Collaborations; Communities; Computational Biology; Development; Diagnostic; Disabled Persons; Discipline; Disease; Environment; Epigenetic Process; Event; Gene Fusion; Generations; Genetic; Genomics; Glioblastoma; Glioma; Goals; Human; Image; Immunotherapy; International; Knowledge; Laboratories; Malignant Neoplasms; Mediating; Mentors; Metabolism; Minority; Modality; Molecular; Neurons; Newly Diagnosed; Oncolytic viruses; Participant; Pathway interactions; Patient Care; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Regimen; Research; Research Personnel; Science; Scientist; Therapeutic; Translating; Tumor Subtype; Woman; chimeric antigen receptor T cells; clinical phenotype; genome-wide; improved; innovation; mathematical model; medulloblastoma; meetings; molecular subtypes; multidisciplinary; new technology; next generation; novel; novel strategies; novel therapeutics; prognostic; single cell sequencing; stem cells; symposium; tool; tumor growth; tumor initiation; tumor microenvironment; tumor-immune system interactions

Project Summary Brain tumors are among the most lethal and devastating human cancers. Despite decades of advances in the field, patient outcomes for brain tumors remain poor. However, there has been a recent surge of multidisciplinary discoveries in this field that are likely to impact patient care in a momentous way. The goal of the inaugural Basic Mechanisms to Clinical Trials in Brain Tumors Gordon Research Conference (GRC) multidisciplinary international meeting is to discuss and debate cutting-edge concepts and breakthroughs in the brain tumor field to help develop innovative, mechanism-based diagnostic, prognostic, and therapeutic approaches that will significantly advance the care of brain tumor patients. The meeting will cover both pediatric and adult brain tumors and will focus on (1) deciphering the mechanisms that control normal brain development and how aberrations of such mechanisms produce disease, (2) studying how alterations in molecular pathways (including genetic and epigenetic events) result in clinical phenotypes, (3) understanding how the brain and immune microenvironment affect tumor initiation and growth, and (4) investigating how such knowledge can be translated into improved patient care. Emphasis would be placed on new concepts in brain tumor research, new technological and computational biology approaches, and new therapeutic modalities and their challenges. Laboratory and clinical investigators would develop novel strategies to translate new findings into novel clinical trials. Further, an important feature of the meeting will be bringing together eminent leaders and women, minorities, persons with disabilities, early stage and early established investigators in the field, in order to build relationships and provide mentoring and networking opportunities to cement the commitment of the new generation of scientists and clinicians to the field and provide them with the tools to make a difference in the lives of brain tumor patients, and create opportunities to explore potential collaborations. The meeting will be extensively evaluated by participants, and their ideas and opinions will be discussed in an open meeting and will be taken into consideration in planning for subsequent years.

项目概要 脑肿瘤是最致命和最具破坏性的人类癌症之一。尽管在这方面取得了数十年的进步 领域，脑肿瘤患者的治疗结果仍然很差。然而，最近出现了激增 该领域的多学科发现可能会对患者护理产生重大影响。目标是 首届脑肿瘤临床试验基本机制戈登研究会议 (GRC) 多学科国际会议旨在讨论和辩论前沿概念和突破 脑肿瘤领域，帮助开发创新的、基于机制的诊断、预后和治疗方法 这些方法将显着改善脑肿瘤患者的护理。会议将涵盖两方面内容 儿童和成人脑肿瘤，并将重点关注（1）破译控制正常大脑的机制 发展以及这些机制的畸变如何产生疾病，（2）研究 分子途径（包括遗传和表观遗传事件）导致临床表型，（3）理解 大脑和免疫微环境如何影响肿瘤的发生和生长，以及（4）研究如何影响肿瘤的发生和生长 知识可以转化为改善患者护理。重点将放在大脑中的新概念上 肿瘤研究、新技术和计算生物学方法以及新的治疗方式和 他们的挑战。实验室和临床研究人员将制定新策略来转化新发现 进入新的临床试验。此外，此次会议的一个重要特点是汇聚了杰出领导人 以及妇女、少数群体、残疾人、早期阶段和早期设立的实地调查人员， 为了建立关系并提供指导和交流机会，以巩固承诺 新一代科学家和临床医生进入该领域，并为他们提供改变现状的工具 脑肿瘤患者的生活，并创造探索潜在合作的机会。会议 将由参与者进行广泛评估，并在公开会议上讨论他们的想法和意见 并将在随后几年的规划中予以考虑。