2023 Basic Mechanisms to Clinical Trials in Brain Tumors Gordon Research Conference

2023年脑肿瘤临床试验的基本机制戈登研究会议

• 批准号: 10751111
• 负责人: SADHAN MAJUMDER
• 金额: $ 1.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-22 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10751111
• 关键词: Adult; Affect; Brain; Brain Neoplasms; Breathing; Caring; Cementation; Childhood; Clinical Investigator; Clinical Trials; Collaborations; Communities; Computational Biology; Development; Diagnostic; Disabled Persons; Discipline; Disease; Environment; Epigenetic Process; Event; Gene Fusion; Generations; Genetic; Genomics; Glioblastoma; Glioma; Goals; Human; Image; Immunotherapy; International; Knowledge; Laboratories; Malignant Neoplasms; Mediating; Mentors; Metabolism; Minority; Modality; Molecular; Neurons; Newly Diagnosed; Oncolytic viruses; Participant; Pathway interactions; Patient Care; Patient-Focused Outcomes; Patients; Pharmaceutical Preparations; Regimen; Research; Research Personnel; Science; Scientist; Therapeutic; Translating; Tumor Subtype; Woman; chimeric antigen receptor T cells; clinical phenotype; genome-wide; improved; innovation; mathematical model; medulloblastoma; meetings; molecular subtypes; multidisciplinary; new technology; next generation; novel; novel strategies; novel therapeutics; prognostic; single cell sequencing; stem cells; symposium; tool; tumor growth; tumor initiation; tumor microenvironment; tumor-immune system interactions

Project Summary Brain tumors are among the most lethal and devastating human cancers. Despite decades of advances in the field, patient outcomes for brain tumors remain poor. However, there has been a recent surge of multidisciplinary discoveries in this field that are likely to impact patient care in a momentous way. The goal of the inaugural Basic Mechanisms to Clinical Trials in Brain Tumors Gordon Research Conference (GRC) multidisciplinary international meeting is to discuss and debate cutting-edge concepts and breakthroughs in the brain tumor field to help develop innovative, mechanism-based diagnostic, prognostic, and therapeutic approaches that will significantly advance the care of brain tumor patients. The meeting will cover both pediatric and adult brain tumors and will focus on (1) deciphering the mechanisms that control normal brain development and how aberrations of such mechanisms produce disease, (2) studying how alterations in molecular pathways (including genetic and epigenetic events) result in clinical phenotypes, (3) understanding how the brain and immune microenvironment affect tumor initiation and growth, and (4) investigating how such knowledge can be translated into improved patient care. Emphasis would be placed on new concepts in brain tumor research, new technological and computational biology approaches, and new therapeutic modalities and their challenges. Laboratory and clinical investigators would develop novel strategies to translate new findings into novel clinical trials. Further, an important feature of the meeting will be bringing together eminent leaders and women, minorities, persons with disabilities, early stage and early established investigators in the field, in order to build relationships and provide mentoring and networking opportunities to cement the commitment of the new generation of scientists and clinicians to the field and provide them with the tools to make a difference in the lives of brain tumor patients, and create opportunities to explore potential collaborations. The meeting will be extensively evaluated by participants, and their ideas and opinions will be discussed in an open meeting and will be taken into consideration in planning for subsequent years.

项目摘要 脑肿瘤是最致命和最具破坏性的人类癌症之一。尽管几十年来， 然而，脑肿瘤患者的预后仍然很差。然而，最近出现了一股 这一领域的多学科发现可能会以重大方式影响患者护理。的目标 首届脑肿瘤临床试验的基本机制戈登研究会议（GRC） 多学科国际会议是讨论和辩论的前沿概念和突破， 脑肿瘤领域，以帮助开发创新的，基于机制的诊断，预后和治疗 这些方法将大大促进脑肿瘤患者的护理。会议将涵盖双方 儿童和成人脑肿瘤，并将重点放在（1）破译控制正常大脑的机制 发展和如何畸变的这种机制产生疾病，（2）研究如何改变， 分子途径（包括遗传和表观遗传事件）导致临床表型，（3）理解 大脑和免疫微环境如何影响肿瘤的发生和生长，以及（4）研究这些微环境如何影响肿瘤的发生和生长。 知识可以转化为更好的病人护理。重点将放在脑的新概念上 肿瘤研究，新技术和计算生物学方法，以及新的治疗方式， 他们的挑战。实验室和临床研究人员将开发新的策略来转化新的发现 进入新的临床试验此外，会议的一个重要特点是将知名领导人聚集一堂， 妇女、少数群体、残疾人、早期和早期建立的实地调查人员， 为了建立关系，并提供指导和网络机会，以巩固承诺， 新一代的科学家和临床医生到该领域，并为他们提供工具，使不同的 在脑肿瘤患者的生活中，并创造机会探索潜在的合作。会议 将接受与会者的广泛评估，并在公开会议上讨论他们的想法和意见 并会在日后的规划中加以考虑。