Hepatitis B & Liver Cancer Prevention in Asian Americans

描述（由申请人提供）：这个健康保护研究倡议指导研究科学家发展奖（K 01）将提供候选人，约翰H。Choe，多学科工具，成为一名独立的研究者，特别关注亚洲移民人群中的B肝炎（HBV）和肝癌控制。为此，崔博士有几个相关的职业目标，将通过拟议的教学课程，临床培训和指导研究活动来实现。其中包括：（1）通过担任弱势群体的指导首席研究员，扩大他的癌症控制研究经验;（2）有助于理解不同亚洲人群之间疾病预防和癌症控制的相似性和差异;（3）通过测试自我报告的健康行为的有效性，推进亚裔美国人的癌症控制和疾病预防研究方法;以及（4）提交R 01拨款申请，以解决韩裔美国人中的B型肝炎和肝癌预防问题。 主要归因于慢性HBV感染率高和疫苗接种率低，肝细胞癌（原发性肝癌）对亚洲人的影响超过美国其他人群。拟议的研究活动将检查乙肝病毒和肝癌检测和疫苗接种率，以及与社会人口统计学和其他因素的关联，在华盛顿州的韩裔美国人中;然后将韩裔美国人的调查结果与以前从华裔美国人社区收集的结果进行比较。在这项指导研究职业发展奖期间，Choe博士提出的研究活动包括：。为韩裔美国人开发一种适合文化的HBV和肝癌实践调查工具，将定性试点研究和Bastani健康行为框架的结果结合起来。 .使用此问卷，以确定社会人口学和其他因素与推荐的HBV检测之间的600名朝鲜族从大都会地区的塔科马，华盛顿。 .比较两个亚裔美国人人群（韩国人和中国人）推荐的HBV检测相关因素的相似性和差异 .通过审查韩裔和华裔美国人中调查参与者的医疗记录子集，对自我报告的HBV检测行为的有效性进行补充分析。 .为韩裔美国人制定和预测试B型肝炎教育干预措施;这将为预期的R 01拨款申请提供可行性和可接受性信息，以解决该人群中的肝癌问题。

DESCRIPTION (provided by applicant): This Health Protection Research Initiative Mentored Research Scientist Development Award (K01) will provide the candidate, John H. Choe, the multidisciplinary tools to become an independent investigator with special focus on hepatitis B (HBV) and liver cancer control in Asian immigrant populations. Toward this end, Dr. Choe has several related career goals that will be achieved through proposed didactic coursework, clinical training, and mentored research activities. These include: (1) To expand his cancer control research experience by serving as the mentored principal investigator in a vulnerable population; (2) To contribute to the understanding of similarities and differences of disease prevention and cancer control across different Asian populations; (3) To advance cancer control and disease prevention research methodology in Asian Americans by testing the validity of self-reported health behavior; and (4) To submit an R01 grant application addressing hepatitis B and liver cancer prevention in Korean Americans. Largely attributable to high rates of chronic HBV infection and low rates of vaccination, hepatocellular carcinoma (primary liver cancer) affects Asians more than other populations in the US. The proposed research activity would examine rates of HBV and liver cancer testing and vaccination, as well as associations with sociodemographic and other factors, among Korean Americans in Washington State; survey results from Korean Americans will then be compared with those collected previously from the Chinese American community. The research activities proposed for Dr. Choe during this mentored research career development award are: . To develop a culturally-appropriate survey instrument of HBV and liver cancer practices for Korean Americans, incorporating results from a qualitative pilot study and Bastani's Health Behavior Framework. . Using this questionnaire, to identify sociodemographic and other factors associated with recommended HBV testing among 600 ethnic Koreans from the metropolitan area of Tacoma, Washington. . To compare the similarities and differences of factors associated with recommended HBV testing across two Asian American populations: Koreans and Chinese . To conduct a supplemental analysis of the validity of self-reported HBV testing behavior by reviewing a subset of survey participant medical records among Korean and Chinese Americans. . To develop and pre-test a hepatitis B educational intervention for Korean Americans; this will provide feasibility and acceptability information for an intended R01 grant application to address liver cancer in this population.