NM Minority Based Community Clinical Oncology Program

描述（由申请人提供）：新墨西哥州的特点是种族多样性和不同寻常的癌症发病率和死亡率模式。相当一部分新墨西哥人是年轻人、农村人、穷人、没有医疗保险和服务不足的人。新墨西哥州的180万居民中，白人占45%，西班牙裔占42%，印第安人占10%，黑人占2%，其他少数民族占1%。除了英语和西班牙语，我们的普韦布洛、纳瓦霍、阿帕奇和乌特印第安部落说着20多种不同的语言和方言。在这种背景下，新墨西哥大学癌症研究和治疗中心（UNM CRTC）的使命是利用其在基础、转化和临床癌症研究、癌症流行病学和社区干预方面的专业知识，降低新墨西哥州多种族人群的癌症发病率和死亡率。参与由美国国家癌症研究所（NCI）和MB-CCOP项目赞助的癌症预防和治疗合作试验是这一使命的重要组成部分。自1975年中心成立以来，CRTC的研究人员一直在为NCI项目贡献患者和科学专业知识。CRTC目前由NCI P20癌症中心规划拨款资助，拥有优秀的研究和初级癌症预防项目，总同行评审资金为8300万美元。其中包括新墨西哥州肿瘤登记处（NMTR），它是最初的监测、流行病学和最终结果（SEER）项目之一，现在是NCI资助的第30个年头。NMTR拥有世界上最大的关于西班牙裔和美洲原住民癌症发病率和死亡率的数据库，并记录了这些群体中截然不同的癌症发病率和死亡率模式。自2000年8月以来，在MB-CCOP项目的资助下，CRTC正在通过招募14名新的肿瘤临床专家和在新墨西哥大学及其附属机构开发新的扩展临床试验基础设施来建立强大的临床癌症项目。新墨西哥大学癌症中心及其附属机构共同为该州80%的癌症患者提供服务。与新墨西哥州的种族多样性密切相关的是，目前从我们的MB-CCOP项目入组到ncl赞助的治疗和预防试验的患者中有52%是少数民族：31%的西班牙裔，16%的美洲印第安人，4%的亚洲人和1%的黑人。在获得MB-CCOP项目资助之前，CRTC是西南肿瘤学组（SWOG）和儿科肿瘤学组（POG）的成员机构；CRTC教师继续在这些小组中发挥重要的领导作用。其他研究基地包括国家外科辅助乳房和肠项目（NSABP）和最近的东部肿瘤合作小组（ECOG）。MB-CCOP项目的重新拨款将确保少数族裔获得临床试验的机会和收益，加强我们的附属网络，促进与西班牙裔和美洲原住民部落和社区建立临床试验项目，并扩大对少数族裔人口和本地区医疗服务不足人群的服务。

DESCRIPTION (provided by applicant): The State of New Mexico is characterized by ethnic diversity and unusual patterns of cancer incidence and mortality. A substantial number of New Mexicans are young, rural, poor, and medically uninsured and underserved. With a higher percentage of Hispanics and Native Americans than any other State, New Mexico's 1.8 million citizens are 45% White, 42% Hispanic, 10% Native American, 2% Black, and 1% other ethnic minorities. In addition to English and Spanish, our Pueblo, Navajo, Apache, and Ute Indian Tribes speak over twenty different languages and dialects. In this context, the mission of the University of New Mexico Cancer Research and Treatment Center (UNM CRTC) is to use its expertise in basic, translational, and clinical cancer research, cancer epidemiology, and community intervention to reduce the incidence and mortality of cancer in New Mexico's multiethnic populations. Participation in cooperative cancer prevention and treatment trials sponsored by the National Cancer Institute (NCI) and the MB-CCOP program, is a critical part of this mission. CRTC investigators have been contributing patients and scientific expertise to the NCI program since the Center opened in 1975. Currently funded with an NCI P20 Cancer Center Planning Grant, the CRTC has excellent research and primary cancer prevention programs supported by $83 million in total peer-reviewed funding. Among these is the New Mexico Tumor Registry (NMTR), one of the original Surveillance, Epidemiology and End Results (SEER) programs, now in its 30th year of NCI funding. The NMTR holds the world's largest database on cancer incidence and mortality in Hispanics and Native Americans and has documented strikingly different patterns of cancer incidence and mortality in these groups. Funded under the the MB-CCOP program since August 2000, the CRTC is building strong clinical cancer programs through the recruitment of 14 new oncology clinical specialists and the development of a new expanded clinical trials infrastructure at UNM and its affiliate sites. Together, the UNM CRTC and its Affiliates serve 80% of the cancer patients in the State. In close parallel with New Mexico's ethnic diversity, 52% of the patients currently enrolled from our MB-CCOP program to NCl-sponsored treatment and prevention trials are ethnic minorities: 31% Hispanic, 16% American Indian, 4% Asian, and 1% Black. Prior to being funded as a MB-CCOP program, the CRTC was a member institution of the Southwest Oncology Group (SWOG) and the Pediatric Oncology Group (POG); CRTC faculty continue to play significant leadership roles in these groups. Additional Research Bases include the National Surgical Adjuvant Breast and Bowel Project (NSABP) and most recently, the Eastern Cooperative Oncology Group (ECOG). Renewed funding of this MB-CCOP program will insure increased access and accrual of minorities to clinical trials, strengthen our Affiliate Network, facilitate the building of clinical trials programs with Hispanic and Native American Tribes and communities, and expand outreach to minority populations and the medically underserved in our region.