ACT 3: RESOURCE CENTER FOR CELL IMAGE ANALYSIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。波多黎各大学医学校区图像分析资源中心(IARC)成立于1996年。国防部在1993年的前一次仪器拨款提供了基本设备。从1996年至2001年，皇家医学中心提供资金购买更多的设备，并提供技术支助，培训调查人员使用图像分析和监督设施。第二个供资周期的主要目标是扩大现有设施，使更多的调查人员能够使用这些设施，并将图像分析改造成五年后能够自给自足的设施。这项活动的具体目标是：(1)提供必要的基础设施，以便研究人员能够利用图像分析以快速和有效的方式量化数据。2)增加IARC的其他功能，如共焦显微镜和振动刀，以获得更厚的组织切片，以便在共焦显微镜下观察。3)通过向研究人员介绍免费的成像软件“NIH Image”，提供关于MCID和NIH成像软件包的讲习班和培训，广泛传播和传播图像分析技术。4)将目前的IARC转变为一个自给自足的单位。最初，确定了五名调查人员，他们的项目迫切需要高质量的图像分析。这些调查人员为他们的研究提供了积极的资金，或者最近向联邦资助机构提交了拨款申请，正在等待决定。他们的研究领域是：肾素-抗紧张素系统与心肌病，性类固醇与神经精神障碍，艾滋病与感觉性肌病，肾上腺素与神经再生，药物滥用的激励方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Image Analysis Resource Center (IARC) of the Medical Sciences Campus of the University of Puerto Rico was established in 1996. A previous instrumentation grant from the Department of Defense in 1993 provided the basic equipment. From 1996-2001 RCMI provided funds to purchase additional equipment and also technical support to train investigators in the use of Image Analysis and to supervise the facilities. The main objective of this second cycle of funding was to extend the current facilities to make them available to a larger population of investigators and to transform the Image Analysis into a facility that would be self sufficient after five years. The specific aims of this activity were: (1) To provide the infrastructure necessary so that researchers can use image analysis to quantify data in a fast and efficient manner. 2) To add additional capabilities to the IARC, such as confocal microscopy, and a vibratome to obtain thicker tissue sections for viewing under the confocal microscope. 3) To widely idstribute and disseminate image analysis technology by introducing investigators to the free imaging solftware "NIH Image", offering workshops and training investigators on the MCID and NIH imaging software packages. 4) To convert the current IARC into a self-supporting unit. Originally, five investigators were identified, who had projects with immediate need for high quality Image Analysis. These investigators had active funding for their research or had recently submitted grant applicadtions to federal funding agencies and are awaiting a decision. Their research areas were: The renin-antiotensin system and cardiomyopathy, sex steroids and neuropsychiatric disorders, AIDS and sensory myopathies, ephrins and nerve regeneration, motivational aspects of drug abuse.