GENOTOXIC EFFECTS IN RATS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。砷是一种公认的人类致癌物质，几乎在所有环境介质中以低浓度普遍存在。据报道，急性接触三氧化二砷会导致死亡和/或多器官损害，症状包括恶心、呕吐、腹泻、胃肠道出血、脑水肿、心动过速、心律失常和低血容量性休克。虽然流行病学数据已经确定无机砷是一种人类致癌物质，但动物研究并没有得到很好的界定。无机砷在动物，主要是啮齿动物中的致癌性一直是争论的主题，因为数据集有限，一些早期研究的设计被认为是不充分的，而且它的遗传毒性还没有得到充分的表征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Arsenic is a well-established human carcinogen and is ubiquitous in low concentration virtually in all the environment media. Acute exposure to arsenic trioxide has been reported to induce death and/or multiple organ damage with symptoms including nausea, vomiting, diarrhea, gastrointestinal hemorrhage, cerebral edema, tachycardia, dysrhythmias, and hypovolemic shock. Although epidemiological data have firmly established inorganic arsenic to be a human carcinogen, animal studies are less well defined. The carcinogenicity of inorganic arsenic in animals, primarily rodents, has been the subject of debate due to the limited data set, the perceived inadequacy in the design of some of the earlier studies and its genotoxicity that has not been fully characterized