Enhancement of the Capacity for Biomedical Research (RCMI)

描述（由申请人提供）：莫尔豪斯医学院的最终研究目标是达到与任何医疗机构相当的生物医学研究能力和生产力水平。为了实现这一目标，在这个为期五年的续期申请中请求资金，总主题为：“组织保护和修复机制”。在这个应用程序中，我们计划(1)将研究核心活动整合到包含类似技术的分组中，并在重组的核心中构建新技术，这将使MSM能够朝着建立一个研究密集环境的目标前进。这些核心将：(2)促进我们在MSM应用主题下的研究重点领域的发展，这些领域跨越基础科学和临床学科，并且适合学校的使命。这将通过资助技术薪金和有限的非人员支助来实现：(a)在四个研究领域开展合作研究活动：癌症、传染病、生殖生物学和血管生物学；(b)通过研究项目的发展来发展教员基础设施通过这些针对新教员或初级教员的个人研究项目。我们还计划在本申请周期的第3-5年资助第二组开发应用（一到两个），我们设想每年在MSM建立一个年度研究研讨会，重点关注我们研究主题下的不同研究领域。(3)最后，我们计划通过招募博士后候选人，并通过全面的发展计划来提升他们的职业生涯，扩大我们现有的艾滋病Nef发病机制研究团队，扩大我们的艾滋病研究领域。同时，我们将建立必要的组织结构，以加强发病机制小组的研究和资助。这几个目标的实现将把莫尔豪斯医学院推向卓越生物医学研究的新平台，并为抗击艾滋病和其他影响医疗服务不足人群的疾病做出重大贡献。

DESCRIPTION (provided by applicant): The ultimate research goal of the Morehouse School of Medicine is to achieve a level of biomedical research capability, and productivity that is equal to that of any medical institution. Toward that goal, funds are requested in this five year renewal application with the overall topic of: "Tissue Protection and Reparative Mechanisms". In this application we plan to (1) consolidate research core activities into groupings encompassing similar technologies, and build new technologies within the reorganized cores that will allow MSM to move ahead in its goal of building a research intense environment. These cores will: (2) foster development of research focus areas falling under the umbrella of our application topic at MSM, which cross basic science and clinical disciplines, and are appropriate to the school's mission. This will be accomplished through funding technical salaries and limited non-personnel support for (a) the development of collaborative research activities in four research areas: Cancer, Infectious Diseases, Reproductive Biology, and Vascular Biology; and (b) development of faculty infrastructure through the development of research programs through these individual research projects for new or junior faculty members. We also plan to fund a second set of developmental applications (one or two) during Years 3-5 of this application cycle, and we envision establishing an annual Research Symposium at MSM focused each year on a different research area falling under our research topic. (3) Finally, we plan to extend our current AIDS Nef Pathogenesis research team, and expand our AIDS focus area, through recruitment of postdoctoral candidates, and enhancing their careers through a comprehensive developmental program. Simultaneously, we will establish the organizational structure necessary to enhance the research and the funding of the pathogenesis group. Achievement of these several objectives will move Morehouse School of Medicine to a new plateau of biomedical research excellence, and make substantial contributions to the fight against AIDS and other diseases that affect underserved populations.