Synthesis of Biologically Active Macrocycle Molecules

描述（由申请人提供）：本生物活性大环分子合成项目旨在在合成和研究结构复杂的生物活性天然产物过程中发明、开发和应用合成方法（特别是新型金属介导方法）。本文开发的合成方法和策略将有助于评估和研究靶向分子和相关分子的生物学特性。该计划将集中在三个领域：（a）合成一类新的血小板活化因子（PAF）拮抗剂，称为phomactins。PAF是一种在人体内普遍存在的化合物，与呼吸系统、炎症和心血管疾病有关。phomactins是独特的选择性PAF拮抗剂，因为它们对腺苷二磷酸、花生四烯酸或胶原诱导的血小板聚集没有影响。(b)两性霉素A及其相关分子的合成。这些结构上引人注目的化合物被认为对所有60种NCI癌症筛选都有活性，尤其表现出急性抗白血病特性，以及对兔骨骼肌肌动蛋白ATP酶的活性。(c)抗人支气管-肺非小细胞肺癌活性海洋天然产物superstimulus A的合成。非小细胞肺癌占肺癌的绝大多数。不幸的是，针对NSCLC的化疗尚未证明非常成功。Superstaglandin A对耐药鼠白血病细胞也有活性。这种巨大的生物学潜力使superstaglandin A成为全合成的非常有吸引力的候选者。

DESCRIPTION (provided by applicant): This project on the synthesis of biologically active macrocyclic molecules aims to invent, develop, and apply synthetic methods (particularly novel metal mediated methods) during the synthesis and study of architecturally complex bioactive natural products. The synthetic methods and strategies developed herein will facilitate the evaluation and study of the biological properties of the targeted and allied molecules. The program will concentrate in three areas: (a) Synthesis of a new class of platelet activating factor (PAF) antagonists known as the phomactins. PAF is a compound ubiquitous to the human body and implicated in respiratory, inflammatory, and cardiovascular diseases. The phomactins are uniquely selective PAF antagonists as they have no effect on adenosine diphosphate, arachidonic acid, or collagen-induced platelet aggregation. (b) Synthesis of amphidinolide A and allied molecules. These structurally striking compounds are deemed active against all 60 NCI cancer screens and exhibit especially acute antileukemic properties, as well as activity towards rabbit skeletal muscle actomysion ATPase. (c) Synthesis of superstolide A, a marine natural product with excellent activity against human bronchpulmonary non-small cell lung carcinoma. Non-small cell lung carcinoma accounts for the large majority of lung cancers. Unfortunately chemotherapy against NSCLC has yet to prove very successful. Superstolide A is also active against resistant murine leukemia cells. Such tremendous biological potential makes superstolide A a very attractive candidate for total synthesis.