SYNTHESIS OF BIOLOGICALLY ACTIVE MACROCYCLIC MOLECULES

我们的目标是发明、开发和应用合成方法来 结构复杂的生物活性天然产物的合成与研究 产品。该方案将集中在三个领域：a) 一类结构独特的海洋漏斗凝胶大环化合物的合成 化合物，也就是褐马菌素。幽灵蛋白可以影响细胞的功能 血小板活化因子(PAF)。B)合成一系列 新的大内酯类化合物，称为两性内酯。这些化合物具有 诱人的生物学特征，尤指抗白血病特性，如 以及对兔骨骼肌肌动ATPase的活性。c) 与这些合成企业相结合，计划推出新的 有机金属和自由基反应的设计和 调查过了。特别感兴趣的包括开发 以钯、铟、锡和硅为原料的催化方法 以及复杂分子中1，2-Wittig重排反应的研究 综合。为了支持这项研究，低分辨率和高分辨率 FAB-MS数据是必需的。

Our objective to invent, develop, and apply synthetic methods to the synthesis and study of architecturally complex bioactive natural products. The program will concentrate in three areas: a) the synthesis of a structurally unique class of marine fungel macrocyclic compounds, the phomactins. Phomactins can effect the function of platelet-activating factor (PAF). b) the synthesis of a series of novel macrolactones known as the amphidinolides. These compounds have attractive biological features, especially antileukemic properties as well as activity towards rabbit skeletal muscle actomysion ATPase. c) in conjunction with these synthetic ventures it is planned that new organometallic and free radical reactions be designed and investigated. Particular interests include the development of catalytic methods involving palladium, indium, tin, and silicon as well as a study of the 1,2-Wittig rearrangement in complex molecule synthesis. In support of this research, low and high resolution FAB-MS data are required.