THE GLIDING MOTILITY AND CELL INVASION BY PLASMODIUM

描述(申请人提供)：无纤毛或鞭毛 但在固体基质上快速滑行。这一独特的分子机制 运动类型不明。我们已经提供了诱捕的基因证据 (血栓反应蛋白相关匿名蛋白)，一种典型的跨膜分子 带有两个粘附域的，是运动和细胞所必需的 疟原虫子孢子的入侵。有人认为，滑翔和细胞 侵袭是由位于质膜下的肌动蛋白/肌球蛋白马达驱动的。 寄生虫的数量。这项建议的总体目标是确定 电机组件，其中一些必须直接或间接连接到 TRAP的细胞质尾巴。

DESCRIPTION (provided by applicant): Apicomplexa do not have cilia or flagella but glide rapidly on solid substrates. The molecular mechanism of this unique type of motility is obscure. We have provided genetic evidence that TRAP (thrombospondin-related anonymous protein), a typel trans-membrane molecule that bears two adhesive domains, is required both for motility and cell invasion of Plasmodium sporozoites. It has been suggested that gliding and cell invasion is driven by an actin/myosin motor located beneath the plasma membrane of the parasites. The overall objective of this proposal is to identify the motor components, some of which must be directly or indirectly connected to the cytoplasmic tail of TRAP.