Endocrine Function and Mood in Bipolar Disorder

描述（由申请人提供）： 这是R 01补助金的修订申请：“生殖内分泌功能和情绪， 患有躁郁症的女性“我们将评估双相情感障碍（BPD）治疗女性的生殖内分泌功能。我们已经收集了试点数据，这表明BPD妇女有月经和代谢功能障碍的频率增加。 采用横断面设计，本研究将前瞻性评估60名接受标准药物治疗的双相情感障碍女性（年龄20-35岁）连续三个月经周期的生殖内分泌功能和情绪，并与30名年龄和BMI匹配的健康对照组进行比较。后者可能会影响月经功能。受试者将接受精神病评估、体格检查和激素筛查。我们将通过使用ChronoRecord软件进行每日自我报告来监测药物对生殖内分泌功能和情绪的影响。 此外，我们还将评估当前用药状态（例如，情绪稳定剂和非典型抗精神病药物的摄入）对生殖功能的影响。该项目将通过以下方式扩展双相情感障碍女性生殖生物学的现有知识：（1）确定BPD女性与健康对照组相比生殖功能障碍的频率;（2）确定生殖功能障碍的预测因素;（3）制定指南，以尽量减少对BPD治疗女性生殖健康的潜在不良影响。

DESCRIPTION (provided by applicant): This is a revised application for an R01 grant: "Reproductive endocrine function and mood in women with bipolar disorder." We will evaluate reproductive endocrine function in women treated for bipolar disorder (BPD). We have collected pilot data, which suggest that women with BPD have an increased frequency of menstrual and metabolic dysfunction. Using a cross-sectional design, this study will prospectively evaluate reproductive endocrine function and mood for three consecutive menstrual cycles in 60 women (ages 20-35) treated for bipolar disorder with standard medications compared to 30 age- and BMI-matched healthy controls. The latter of which may affect menstrual function. Subjects will receive psychiatric evaluation, physical examination and hormonal screening. We will monitor medication effects on both reproductive endocrine function and mood by utilizing ChronoRecord software for daily self-reporting. In addition, we will assess the impact of current medication status (e.g. intake of mood stabilizers and atypical antipsychotics) on reproductive function. This project will expand current knowledge of reproductive biology in women with bipolar disorder by: (1) determining the frequency of reproductive dysfunction in women with BPD compared to healthy controls; (2) identifying predictors for reproductive dysfunction; and (3) developing guidelines to minimize potential adverse effects on the reproductive health of women treated for BPD.