REPRODUCTIVE ENDOCRINE FUNCTION AND MOOD IN WOMEN WITH BIPOLAR DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目将扩大双相情感障碍妇女生殖生物学的现有知识，并评估当前药物状况的影响(例如，情绪稳定剂和非典型抗精神病药物的摄入)。这是一项R01拨款：“双相情感障碍女性的生殖内分泌功能和情绪。”我们将评估双相情感障碍(BPD)患者的生殖内分泌功能。我们已经收集了试点数据，这些数据表明患有BPD的女性月经和代谢功能障碍的频率增加。使用横断面设计，这项研究将前瞻性地评估60名接受标准药物治疗的BPD女性(年龄20-35岁)连续三个月经周期的生殖内分泌功能和情绪，并与30名年龄和体重指数匹配的健康对照组进行比较。受试者将接受精神评估、体检和激素筛查。我们将利用ChronoRecord软件进行每日自我报告，监测药物对生殖内分泌功能和情绪的影响。此外，我们将评估目前的药物状况(例如情绪稳定剂和非典型抗精神病药物的摄入)对生殖功能的影响。该项目将通过以下方式扩大BPD妇女生殖生物学的现有知识：(1)确定与健康对照相比，BPD妇女生殖功能障碍的频率；(2)确定生殖功能障碍的预测因素；(3)制定指南，最大限度地减少对接受BPD治疗的妇女生殖健康的潜在不利影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will expand current knowledge of reproductive biology in women with bipolar disorder as well as assessing the impact of current medication status (e.g. intake of mood stabilizers and atypical antipsychotics). This is an R01 grant: "Reproductive endocrine function and mood in women with bipolar disorder." We will evaluate reproductive endocrine function in women treated for bipolar disorder (BPD). We have collected pilot data, which suggest that women with BPD have an increased frequency of menstrual and metabolic dysfunction. Using a cross-sectional design, this study will prospectively evaluate reproductive endocrine function and mood for three consecutive menstrual cycles in 60 women (ages 20-35) treated for BPD with standard medications compared to 30 age- and BMI-matched healthy controls. Subjects will receive psychiatric evaluation, physical examination and hormonal screening. We will monitor medication effects on both reproductive endocrine function and mood by utilizing ChronoRecord software for daily self-reporting. In addition, we will assess the impact of current medication status (e.g. intake of mood stabilizers and atypical antipsychotics) on reproductive function. This project will expand current knowledge of reproductive biology in women with BPD by: (1) determining the frequency of reproductive dysfunction in women with BPD compared to healthy controls; (2) identifying predictors for reproductive dysfunction; and (3) developing guidelines to minimize potential adverse effects on the reproductive health of women treated for BPD.