Training Program in Developmental Biology

描述（由申请人提供）：这是一个竞争性的发展生物学前和博士后培训计划。拟议的培训计划包括来自大学多个学院和部门的教师，反映了宾夕法尼亚大学发育生物学研究和培训的重大扩张。这一扩展包括细胞和发育生物学部门的形成以及发育生物学的研究生培训计划。建议的博士前和博士后培训经验主要集中在利用多种脊椎动物、无脊椎动物和植物生物进行胚胎发育基本机制的实验室研究培训。它促进了现代遗传、细胞和分子方法在发育研究中的应用。研究培训领域包括转录和细胞信号机制，控制细胞谱系的确定，分化和迁移，器官发生，细胞衰老，形态发生和模式形成。学员也有机会接触基因治疗、胎儿手术和遗传发育疾病的相关临床研究。为了准备他们的研究训练，博士预科学生在既定的学习课程中接受正式的指导，包括发育生物学的讲座课程和关于发育机制和疾病的遗传、细胞和分子方法的高级研讨会。Pre- and - postdoctoral学生还可以参加一个发育生物学杂志俱乐部，一个研讨会项目，一个选定主题的研究讨论小组，以及一个年度科学研讨会。学员每学期在学员和培训者的非正式会议上展示他们的研究成果。这一培训的目标是为学员在学术机构和政府机构或生物技术工业中担任发育生物学领域的独立调查人员做好准备。

DESCRIPTION (provided by applicant): This is a competitive renewal for a pre- and postdoctoral training program in developmental biology. The proposed training program includes faculty from multiple schools and departments within the University and reflects a major expansion of developmental biology research and training at Penn. This expansion includes the formation of a Department of Cell and Developmental Biology and a graduate training program in developmental biology. The proposed pre- and postdoctoral training experience is centered primarily on training in laboratory research in basic mechanisms of embryonic development using a diversity of vertebrate, invertebrate, and plant organisms. It fosters the application of modern genetic, cellular, and molecular approaches to developmental studies. Research training areas include transcription and cell signaling mechanisms that control cell lineage determination, differentiation and migration, organogenesis, cellular senescence, morphogenesis, and pattern formation. Trainees also have opportunities for exposure to relevant clinical research in gene therapy, fetal surgery and genetic diseases of development. In preparation for their research training, predoctoral students receive formal instruction in an established curriculum of study, including lecture courses in developmental biology and advanced seminars on genetic, cellular, and molecular approaches to developmental mechanisms and disease. Pre- and postdoctoral students also participate in a developmental biology journal clubs, a seminar program, research discussion groups on selected topics, and an annual scientific symposium. Trainees present their research findings each semester at an informal meeting of trainees and trainers. The objectives of this training are to prepare trainees for careers as independent investigators in the field of developmental biology in academic and governmental institutions or in the biotechnology industry.