Anosteocytic bone remodelling as a potential evolutionary biomimetic route for tissue engineering

骨折是世界各地的公共卫生问题，并造成严重的经济负担，预计随着人口老龄化和相关疾病（如骨质疏松症）患病率的增加而增加。组织工程已经从不同的角度解决了这个问题，建立在我们的自然能力，再生骨。再生医学可以受益于探索可能被刺激以诱导骨重建的新兴机制，采用进化仿生策略。

Bone fractures are a public health issue around the world and pose a serious economic burden, and are expected to increase with an ageing population and the increased prevalence of associated disorders such as osteoporosis. Tissue engineering has been tackling this issue from different angles, building on our natural capability to regenerate bone. Regenerative medicine could benefit from exploration of emerging mechanisms that might be stimulated to induce bone reconstruction, adopting an evolutionary biomimetic strategy.