MOUSE GENETICS CORE

听力丧失是人类最常见的感觉缺陷。在美国，先天性、围产期或早发性听力损失的发生率约为千分之七。在50%的病例中，遗传因素是已知或怀疑的，在小鼠和斑马鱼身上可用的强大的分子和遗传技术是研究听力生物学的有用模型系统。小鼠与人类听觉功能的相似性使小鼠成为临床观察听力损失的特别有吸引力的模型。为了支持小鼠用户研究听觉系统功能，Core D将提供专业的小鼠饲养（接收、设置杂交、断奶、培养、背景转移等）、基因分型和通知/交付请求小鼠给用户。老鼠护理的每日费用将由用户负责，前提是他们有一个资助的项目，包括支持老鼠笼的费用。为鼓励创新和新的合作项目，我们将为共同对照动物和已获批准的资金过渡项目提供每日津贴。将定期审查Core D提供的所有服务，以确保质量和可及性。

Hearing loss is the most frequent sensory defect in humans. Congenital, perinatal or early onset hearing loss occurs in approximately 7 out of 1000 neonates in the United States. In 50% of these cases, a genetic contribution is known or suspected, the powerful molecular and genetic techniques available in mouse and zebra fish are useful model systems for studying the biology of hearing. The functional similarities between mouse and human audition make mouse a particularly attractive model for hearing loss observed clinically. In support of Users of mice to study auditory system function, Core D will provide expert mouse husbandry (receiving, setting up crosses, weaning, fostering, background transfers, etc), genotyping, and notification/delivery of requested mice to Users. Per diem charges for mouse care will be the responsibility of the User, provided that they have a funded project that includes support for mouse cage costs. To encourage innovative and new collaborative projects, we will provide per diem support for common control animals and for approved projects in funding transition. All services provided by Core D will be reviewed periodically to ensure quality and accessibility. The Genetics Core will provide services for a variety of Users. Efficiency of mouse care will be increased greatly by having centralized, expert mouse husbandry and genotyping. Users not proficient in mouse care will gain access the vast number of identified gene knockout mice and defined spontaneous mutants to further their research. Experienced mouse users will benefit from the familiarity of the Core staff with mouse behavior and care, providing better health and higher fecundity for their strains. Training in husbandry, genotyping, and behavioral characterization will be available to all Users and their lab personnel. To encourage interactions and new collaborations, information about the strains, techniques, and projects being pursued by all Users of the Core will be disseminated online and in Genetics Core User meetings.