CORE-- Developmental Susceptibility

描述（由申请人提供）：本核心的目的是促进合作 多学科研究计划，研究生命周期中特定阶段的环境暴露如何影响对疾病和发育缺陷的易感性。的目标 发展易感性研究的核心是：促进和扩大对脆弱发展阶段暴露影响的合作研究，包括怀孕、出生缺陷、神经发育缺陷、儿童癌症和哮喘的不良后果;建立有效的机制，分享想法，讨论正在进行的研究，并促进新的跨学科的企业，整合实验室，临床，和流行病学方法的发展研究，并促进纳入分子和遗传标记到传统的流行病学研究的生殖和发育的结果。核心研究人员从事广泛的研究，从胚胎发育和出生缺陷机制的研究到与妊娠并发症和不良后果、神经发育和儿童癌症有关的环境和职业暴露的流行病学调查。

Description (provided by applicant): The purpose of this Core is to stimulate a collaborative multidisciplinary program of research on how environmental exposures at particular stages in the life cycle affect susceptibility to disease and to deficits in development. The objectives of the Developmental Susceptibility Research Core are to: foster and expand collaborative research on the effects of exposures during vulnerable stages in development, including adverse outcomes of pregnancy, birth defects, neurodevelopmental deficits, childhood cancer, and asthma; establish effective mechanisms for sharing ideas, discussing research in progress, and fostering new interdisciplinary ventures that integrate laboratory, clinical, and epidemiologic approaches to developmental studies; and promote incorporation of molecular and genetic markers into traditional epidemiology studies of reproductive and developmental outcomes. Developmental Susceptibility Core investigators are engaged in a broad spectrum of research ranging from studies of embryologic development and mechanisms of birth defects to epidemiologic investigations of environmental and occupational exposures in relation to complications and adverse outcomes of pregnancy, neurodevelopment, and childhood cancer.