High Frequency Ultrasound Arrays : Intracardiac Imaging

描述(由申请人提供)：超声心动图的广泛应用， 包括经食道回声、血管内回声和心内回声 是推动新技术发展的最肥沃的地区之一 超小型化和非常高的分辨率。时间最长、时间最长的 详细的介入插管程序，电生理 标测和消融治疗复发性房性和室性心律失常 最近受到关注，因为现在公认的空间需求 标测除了透视导管定位外，由于 这些衰弱的节律问题在衰老中的频率增加 人口。我们计划设计、开发和测试2D和3D系列 超声成像设备，在10-15 MHz的工作频率下，将提供 空间定位，以及组织速度和应变率估计 心房和室壁的机械激活，以引导电 映射。这应该会大大缩短将关键区域本地化的时间。我们的 设备将与EP电极和射频消融设备集成在一起，以便 他们可以解剖地监测消融过程，可视化 并绘制射频聚焦期间的温度分布图。这个 我们将制造的设备还可以在之前、期间和之后评估心脏 冠状动脉介入治疗的外科手术及监测 动脉、瓣膜或先天性心脏病。我们的合作伙伴关系是 由临床医生、外科医生、超声心动图医生和 OHSU的电生理学家，由医学博士大卫·J·萨恩领导 与生物工程师相结合的心脏成像跨学科计划 包括：马修·奥唐奈，博士，生物医学系主任 密歇根大学安娜堡分校工程学；Kirk Shung博士，主任 美国国立卫生研究院开发高频阵列的研究资源 宾夕法尼亚州立大学，大学园区；卡尔·托梅纽斯，博士，项目 通用电气公司研究和超声研究经理 纽约斯克内克塔迪发展中心；副总裁道格拉斯·斯蒂芬斯 JOMED成像部门战略技术主管(前身为Endowonics 位于加利福尼亚州兰乔科尔多瓦的小型化阵列的先驱 用于血管内和心脏内成像导管的设备；以及Raymond Chia， 欧文生物医学博士，这是一家敏捷的小公司，在转向方面拥有专业知识 多极电极和消融设备及其与其他设备的组合 成像方式。这些设备的设计和开发结合了 先进的功能成像方法应为以下领域的应用开辟新的前景 有创性超声心动图和超声检查。

DESCRIPTION (provided by applicant): lnvasive applications of echocardiography, including transesophageal echo, intravascular echo and intracardiac echo have been one of the most fertile areas driving new technology for ultraminiaturization and very high resolution. Among the most prolonged and detailed interventional catheterization procedures, electrophysiological mapping and ablation for recurrent atrial and ventricular arrhythmias have received recent attention because of the now-recognized need for spatial mapping in addition to fluoroscopic catheter localization, and because of the increased frequency of these debilitating rhythm problems in an aging population. We propose to design, develop and test a family of 2D and 3D ultrasound imaging devices which, at 10-15MHz operating frequency, will provide spatial localization, and both tissue velocity and strain rate estimates of mechanical activation in atrial and ventricular walls, to guide electrical mapping. This should greatly shorten time to localize critical areas. Our devices will be integrated with the EP electrode and RF ablation devices so that they can anatomically monitor the ablation procedure, visualize the lesion, and map the distribution of temperature during RF delivery focus. The devices we will build can also assess the heart before, during and after surgery as well as monitor anatomical catheter interventions for coronary artery, valvular or congenital heart disease. Our partnership is a multidisciplinary group of clinicians, surgeons, echocardiographers and electrophysiologists at OHSU, led by David J. Sahn, MD, Director of the Interdisciplinary Program For Cardiac Imaging, combined with bioengineers including: Matthew O'Donnell, PhD, Chair of the Department of Biomedical Engineering at the University of Michigan, Ann Arbor; Kirk Shung, PhD, director of an NIH Research Resource for Development of High Frequency Arrays at Pennsylvania State University, University Park; Kal Thomenius, PhD, Program Manager of Ultrasound Research at the General Electric Corporate Research and Development Center in Schenectady, New York; Douglas Stephens, Vice President of Strategic Technology at the Imaging Division of JOMED (formerly Endosonics Corporation) in Rancho Cordova, California, a pioneer in miniaturized array devices for intravascular and intracardiac imaging catheters; and Raymond Chia, PhD, of Irvine Biomedical, a small agile company with expertise in steerable multipolar electrode and ablation devices and their combination with other imaging modalities. The design and development of these devices combined with advanced functional imaging methods should open new vistas for applications in invasive echocardiography and ultrasound in general.