CONSORTIUM FOR RADIOLOGIC IMAGING OF POLYCYSTIC KIDNEY DISEASE: INNOVATIVE IMAG

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。CRISP全规模研究的目的是进行一项前瞻性纵向试验，以评估磁共振成像的准确性和有效性，以确定ADPKD的疾病进展，ADPKD定义为肾脏和肾囊肿体积随时间的变化。该研究打算将基于MRI的测量作为金标准，目前打算比较超声与MRI在确定横截面和随时间推移的囊性受累程度方面的相对准确性。 1)确定MRI（包括钆增强）是否可检测到ADPKD患者短期内肾脏体积、囊性体积和非囊性肾实质体积的微小变化。 2)确定基于代表性横截面图像的横截面囊肿面积的超声测量值是否与基于通过磁共振成像获得的总肾脏体积和囊肿体积测量值的囊肿体积百分比相似。 3)确定ADPKD患者的肾体积、囊性体积和非囊性肾实质体积变化是否与肾功能变化相关。 4)确定哪些因素可预测疾病进展，疾病进展定义为肾脏总体积、囊肿体积和囊肿体积百分比随时间的增加。 5)确定与进展为肾衰竭的风险较低的ADPKD个体相比，肾体积、囊性体积和非囊性体积的变化以及肾小球滤过率的下降在被归类为高风险的ADPKD个体中是否更大。 6)确定肾脏体积、囊性体积、非囊性肾实质体积变化与ADPKD体征、症状和并发症（包括但不限于高血压的发生、疼痛的频率和严重程度、血尿的频率和持续时间以及一般生活质量）之间是否存在相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the CRISP Full-Scale Study is to conduct a prospective, longitudinal trial to evaluate the accuracy and validity of magnetic resonance imaging to determine disease progression in ADPKD defined as a change in both renal and renal cyst volumes over time. The study intends to consider the MRI based measurements as the gold standard and at present intends to compare the relative accuracy of ultrasound to MRI in determining the extent of cystic involvement cross-sectionally and over time. 1) To determine if MRI including gadolinium enhancement detects small changes in renal volume, cystic volume and non-cystic renal parenchymal volume over a short period of time in ADPKD individuals. 2) To determine if ultrasound measurement of cross-sectional cyst area based on representative cross-sectional images are similar to percent cyst volume based on total renal volume and cyst volume measurements obtained by magnetic resonance imaging. 3) To determine if change in renal volume, cystic volume, and non-cystic renal parenchymal volume will correlate with change in renal function in ADPKD individuals. 4) To determine which factors predict disease progression defined as an increase in total renal volume, cyst volume, and percent cyst volume over time. 5) To determine if changes in renal volume, cystic volume, and non-cystic volume and decline in glomerular filtration rate will be greater in ADPKD individuals categorized as higher risk in comparison to ADPKD individuals categorized as lower risk for progression to renal failure. 6) To determine if correlation between changes in renal volume, cystic volume, non-cystic renal parenchymal volume exists with the occurrence of signs, symptoms and complication of ADPKD including but not limited to, the development of hypertension, frequency and severity of pain, frequency and duration of hematuria and general quality of life.