Functional characterisation of the malaria protein export machinery

疟疾寄生虫能够引起人类最具破坏性的传染病之一，部分原因是它们能够向宿主红细胞输出数百种蛋白质，以获取营养，逃避免疫系统并导致相关病理。最近，我们发现了向宿主细胞输出蛋白质的分子机器，所以现在我们希望确定它是如何工作的，这样就可以定制药物来阻止它杀死这些寄生虫。

The ability of malaria parasites to cause one of the most devastating infectious diseases of humans is in part due to their ability to export hundreds of proteins into their host red blood cells to obtain nutrients, evade the immune system and contribute to associated pathologies. Recently, we discovered the molecular machine that exports proteins into the host cell and so now we wish to establish how it works so that drugs can be tailored to block it to kill these parasites.