EFFECT OF SYSTEMIC LUPUS ERYTHMATOSUS IN MINORITIES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本项目的目的是研究人口统计学、社会经济和遗传因素之间的相互关系，以决定系统性红斑狼疮(SLE)患者的病程和早期结果。这项研究在德克萨斯州的休斯顿和加尔维斯顿以及波多黎各都有中心，除了跟踪非裔美国人和高加索SLE患者外，还在两个不同的地点跟踪西班牙裔患者：德克萨斯州和波多黎各。Lumina研究的另一个方面是Profile分研究。Profile是UAB系统性红斑狼疮遗传学PO1项目的项目4。它的目标是确定遗传学在狼疮预后中所起的作用。因此，不仅获得了患者DNA来研究与SLE相关的基因，而且还招募了父母和兄弟姐妹(三个家庭)，以便也可以分析他们的DNA。到目前为止的结果表明，西班牙裔和非裔美国人的SLE患者发病年龄更早，活动更活跃，社会经济-人口结构不那么有利(拉美裔比非裔美国人更糟糕)，这使他们更容易受到不太有利的自然病史的影响。[Alarc？n，1999]

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to study the inter-relationship between demographic, socioeconomic, and genetic factors in determining the course and early outcome in patients with systemic lupus erythematosus (SLE). This study has centers in Houston and Galveston, Texas as well in Puerto Rico, which in addition to following African-American and Caucasian patients with SLE, follows Hispanic patients at 2 different locations: Texas and Puerto Rico. An added dimension of the LUMINA study is the PROFILE sub-study. PROFILE is Project 4 of the PO1 Program Project in the genetics of SLE at UAB. Its goal is to determine the role that genetics plays in the outcome of lupus. As such, not only is patient DNA obtained to investigate genes related to SLE, but parents and siblings are being recruited (TRIO families) so that their DNA may be analyzed as well. Results to date indicate that Hispanic and African-American patients have more active SLE, at an earlier age of onset, and a less favorable socioeconomic-demographic structure (worse among Hispanics than African-American), which predispose them to a less favorable natural history. [Alarc¿n, 1999]