Blood Pressure in Postmenopausal Women: A GCRC Study

描述(由申请人提供)：这是一份职业中期调查员(K 24)对医学博士Ellen Seely的建议书。这项提议的目标有三个。首先，它将使研究人员能够接受进一步的人类遗传学高级培训，从而增加西利博士研究的深度。其次，这将使研究人员有足够的时间正式培训年轻研究人员在荷尔蒙控制血压领域以患者为导向的研究。第三，这将使研究人员能够利用她作为综合临床研究中心(GCRC)副项目主任的经验，向下一代以患者为导向的研究人员传授如何使用GCRC使用各种基于GCRC的调查技术来研究人类病理生理学。Seely博士的研究主题“绝经后女性的血压：GCRC研究”为K24提供了肥沃的土壤。在美国，高血压影响着2000多万女性，其中大多数是绝经后的女性。尽管高血压在男性和女性中都有明显的遗传成分，但绝经后女性的高血压发病率显著增加，超过了男性，这表明绝经前状态的荷尔蒙环境可能对高血压的表现具有保护作用。Seely博士研究计划的总体目标是利用GCRC对绝经后妇女高血压的病理生理学进行详细研究。西利博士计划研究雌激素对肾素-血管紧张素-醛固酮系统(RAAS)基因多态性的影响。RAAS是血压的主要调节因子。了解雌激素与导致血压降低的RAAS的特定多态之间的相互作用，可能有助于开发具有降压作用的选择性雌激素受体调节剂。因此，这项提案的资金将使西利博士能够扩大她自己的研究事业，同时提供时间来扩大她的导师角色。

DESCRIPTION (provided by applicant): This is a Mid-Career Investigator (K 24) proposal for Ellen Seely, MD. The goal of this proposal is threefold. First, it would increase the depth of Dr. Seely's research by enabling the investigator to receive further advanced training in human genetics. Second, it would give the investigator the supported time to formally train young investigators in patient-oriented research in the field of hormonal control of blood pressure. Third, it would allow the investigator to use her experience as Associate Program Director of the General Clinical Research Center (GCRC) to teach the next generation of patient-oriented researchers about the use of a GCRC for the study of human pathophysiology using varied GCRC-based investigative techniques. Dr. Seely's research topic "Blood Pressure in Postmenopausal Women: a GCRC Study" serves as fertile ground for a K24. Hypertension affects over 20 million women in the United States and the majority of these women are postmenopausal. Although there is clearly a genetic component to hypertension in both men and women, its incidence increases dramatically in women following menopause superceding that in men and suggests that the hormonal milieu of the premenopausal state may be protective against the manifestation of hypertension. The overall goal of Dr. Seely's research plan is to utilize the GCRC for detailed studies of the pathophysiology of hypertension in postmenopausal women. Dr. Seely plans to determine how polymorphisms of genes of the renin-angiotensin-aldosterone system (RAAS), a major regulator of blood pressure, are influenced by estradiol. An understanding of the interaction of estradiol with specific polymorphisms of the RAAS that lead to blood pressure lowering may enable the development of selective estrogen receptor modulators that have antihypertensive effects. Thus, funding of this proposal will allow Dr. Seely to expand her own research career and simultaneously provide time to expand her mentorship role.