Patellofemoral Osteoarthritis Epidemiology

描述（由申请人提供）：我们目前对膝关节骨关节炎（OA）疼痛和残疾的来源的了解有限。先前的研究主要集中在胫股关节（TF）上，并表明结构变化与疼痛和残疾之间的相关性很差。尽管有人认为髌股关节可能与下肢残疾密切相关，但对髌股关节（PF）的关注相对较少，而且对膝关节OA患者的PF关节的评估可以更清楚地解释膝关节疼痛。虽然有关于TF性骨关节炎的良好信息，但髌股骨关节炎的流行病学仍不清楚。此外，目前的数据表明，与疾病相关的危险因素对于PF OA和TF OA是不同的。可能是PF关节特有的危险因素，包括股四头肌力量、腿筋股四头肌肌肉失衡、肌肉质量、髌骨错位和股骨长度与PF OA的关系，其贡献尚不清楚。该项目将利用从一项大规模纵向研究中收集到的数据，该研究包括对膝关节疼痛和残疾的广泛评估，以及对参与者进行的一系列膝关节MRI和x光检查；解决一个整体的具体目标。利用纵向数据（包括序列MRI）探讨PF软骨损失和PF OA的危险因素。在这个项目中，我们将评估PF软骨损失和发展的相同的PF软骨损失相关的症状。

DESCRIPTION (provided by applicant): Our current understanding of the sources of pain and hence disability in knee osteoarthritis (OA) is limited. Previous research has concentrated primarily on tibiofemoral (TF) joints and has shown a poor correlation between structural change and both pain and disability. Relatively little heed has been paid to the patellofemoral (PF) joint, despite suggestions that it may be strongly correlated with lower extremity disability, and that assessment of the PF joint in knee OA provides a clearer explanation for knee pain. Whilst good information is available for TF OA, the epidemiology of patellofemoral OA remains unclear. Moreover current data suggest that the risk factors associated with disease are different for PF OA and TF OA. The contribution of risk factors likely unique to the PF joint including the relationship of quadriceps strength, hamstring quadriceps muscle imbalance, muscle mass, patella malalignment and femur length to PF OA is unknown. This project will take advantage of already collected data from a large-scale longitudinal study that incorporates extensive evaluations of knee pain and disability and serial knee MRI's and x-rays on participants; to address one overall specific aim. Using longitudinal data (including serial MRI) to explore PF cartilage loss, and risk factors for PF OA. In this project we will evaluate PF cartilage loss and development of this same PF cartilage loss associated with symptoms.