Developmental Immunotherapeutics-Allergic Disease/Asthma

嗜酸性胃肠道疾病，包括嗜酸性胃肠炎和嗜酸性食管炎，通常与食物和空气过敏原有关。这些患者中有许多人对食物过敏，这表明这种疾病代表了黏膜耐受性失调的一个例子。我们目前正在招募受试者参加奥马珠单抗(治疗性单抗IgE)治疗嗜酸性胃肠炎的临床试验。这项研究的结果将为抗IgE疗法在嗜酸性胃肠道疾病中的临床应用提供信息。此外，这些结果还将提供有关IgE介导的过程(即刻超敏反应、肥大细胞和嗜碱性粒细胞激活)在嗜酸性胃肠道疾病发病机制中的作用的数据。更好地了解嗜酸性胃肠道疾病将为未来的治疗策略提供基础。 呼吸道炎症是哮喘发病机制的核心，所有哮喘治疗指南都建议对除最轻微哮喘患者外的所有患者进行抗炎治疗。尽管如此，目前还没有临床可用的非侵入性测试来测量哮喘患者的呼吸道炎症。我们目前正在招募受试者参加一项临床研究，利用呼出的呼吸冷凝液作为一种非侵入性技术来测量儿童患者的呼吸道炎症。这项研究的结果将有助于开发非侵入性工具来测量和临床管理哮喘的呼吸道炎症。

Eosinophilic gastrointestinal diseases, including eosinophilic gastroenteritis and eosinophilic esophagitis, commonly associated with food and aeroallergen hypersensitivity. Many of these patients have numerous food allergies, suggesting this disease entity represents an example of dysregulated mucosal tolerance. We are currently enrolling subjects in a clinical trial of omalizumab (therapeutic monoclonal anti-IgE) for eosinophilic gastroenteritis. The results of this study will yield information on the clinical utility of anti-IgE therapeutics in eosinophilic gastrointestinal diseases. Additionally, the results will provide data on the role of IgE mediated processes (immediate hypersensitivity, mast cell and basophil activation) in the pathogenesis of eosinophilic gastrointestinal diseases. Greater understanding of eosinophilic gastrointestinal diseases will provide a basis for future therapeutic strategies. Airway inflammation is central to asthma pathogenesis, and all guidelines for asthma therapy recommends anti-inflammatory therapy for all but the mildest asthma patients. Despite this, there are currently no clinically available non-invasive tests to measure airway inflammation in asthma. We currently are enrolling subjects in a clinical study utilizing exhaled breath condensate as a non-invasive technique to measure airway inflammation in pediatric patients. The results of this study will contribute to the development of non-invasive tools to measure and clinically manage asthmatic airway inflammation.