CT and FTIR Assessment of Bone Structure and Composition

描述（由申请人提供）：最新一代的微计算机断层扫描（microCT）扫描仪，采用改进的束硬化校正，具有同时评估微结构和组织矿化的潜力。骨骼成分分析的第二种新兴模式是傅里叶变换红外微光谱成像（FTIRI），它提供了矿化和矿物质量的补充空间测量。本提案的目的是开发一种同时评估小梁骨结构和成分的方法，结合基于微ct的3D矿化数据和ftiri衍生的2D成分信息，并利用该方法研究人类受试者骨质疏松症进展的影响。探讨成矿措施与形态特征之间的关系。一旦建立，该技术将为骨质量研究提供强大的工具，例如量化与年龄、疾病或药物治疗相关的矿化变化，确定与骨周转率机制相关的空间矿化模式，或探索矿物质量、组织损伤和骨强度之间的关系。

DESCRIPTION (provided by applicant): The newest generation of micro computed tomography (microCT) scanners, incorporating improved beam- hardening corrections, have the potential to provide simultaneous assessment of both micro-architecture and tissue mineralization. A second emerging modality for bone composition analysis is Fourier transform infrared microspectroscopic imaging (FTIRI), which provides complementary spatial measures of mineralization and mineral quality. The objective of this proposal is to develop a method for the simultaneous assessment of trabecular bone structure and composition incorporating microCT-based 3D mineralization data and FTIRI-derived 2D compositional information, and to utilize this method to investigate the effects of osteoporosis progression in human subjects. Relationships among mineralization measures and morphological features will be investigated. Once established, this technique will provide a powerful tool in bone quality studies, for example in quantifying changes in mineralization associated with age, disease, or drug treatment, determining spatial mineralization patterns associated with bone turn-over mechanisms, or exploring relationships between mineral quality, tissue damage, & bone strength.