MRI, MRSI, AND DTI OF BRAIN INJURY IN PRETERM NEONATES

描述（由申请人提供）：该拨款旨在将最先进的神经成像技术应用于早产儿脑损伤的研究。目前，超声波是最常用的技术来成像早产儿的大脑；然而，超声检测到的白质病变不到尸检和MRI检测到的三分之一。此外，超声检查结果并不能解释高达50%的早产儿存在的神经发育问题。初步研究表明，磁共振（MR）成像对早产儿是安全的，解剖磁共振成像在检测早产儿非空洞白质损伤方面比超声更敏感，扩散张量成像（DTI）和磁共振光谱成像（MRSI）评估发育中的大脑的微观结构和代谢，对正常发育的破坏非常敏感，特别是在进行顺序研究时。这项拨款将扩展这些初步研究，以确定核磁共振成像评估的脑代谢改变是否比标准临床和实验室参数与30个月大的运动、视觉和认知结果（由神经运动、眼科检查和贝利婴儿发育量表II评估）有更强的关联，以确定DTI评估的大脑微结构改变是否与标准的临床和实验室参数相比，与30个月的运动、视觉和认知结果（通过神经运动评分、眼科检查和Bayley婴儿发育量表II评估）有更强的相关性。(3)确定mri评估的脑代谢改变或DTI评估的脑微结构改变是否与30个月神经发育结果（通过神经运动评分评估）有更强的相关性。眼科评估和贝利婴儿发育量表II。

DESCRIPTION (provided by applicant): This grant proposes to extend the use of state of the art neuroimaging techniques to the study of brain injury in preterm neonates. Currently, ultrasound is the technique most commonly used to image the brains of preterm neonates; however, ultrasound detects fewer than one third of the white matter lesions detected at autopsy and by MRI. Furthermore, ultrasound findings do not account for the neurodevelopmental problems that have been reported in up to 50% of prematurely born infants. Preliminary studies show that magnetic resonance (MR) imaging is safe in preterm neonates, that anatomic MR imaging has greater sensitivity than ultrasound in detecting noncavitary white matter injuries in preterm neonates, and that diffusion tensor imaging (DTI) and MR spectroscopic imaging (MRSI), which assess the microstructure and metabolism of the developing brain, are very sensitive to disruption of normal development, particularly when sequential studies are performed. This grant will extend these preliminary studies (1) to determine whether alterations of cerebral metabolism, as assessed by MRSI have a stronger association than standard clinical and laboratory parameters with 30 month motor, visual, and cognitive outcome as assessed by neuromotor, ophthalmologic examination, and Bayley's Scales of Infant Development II, (2) to determine whether alterations of cerebral microstructure, as assessed by DTI, have a stronger association than standard clinical and laboratory parameters with 30 month motor, visual, and cognitive outcome assessed by neuromotor scores, ophthalmologic examination, and the Bayley Scales of Infant Development II, and (3) to determine whether alterations of cerebral metabolism, as assessed by MRSI, or alterations of cerebral microstructure, as assessed by DTI, has a stronger association with 30 month neurodevelopmental outcome, as assessed by neuromotor score, ophthalmologic evaluation, and the Bayley's Scales of Infant Development II.