DTI, MRSI, and Volumetry of Cerebellar Injury in Preterm Neonates

项目总结： 在美国出生的儿童中，有13%到16%是早产儿，其中近2%是早产儿 体重不到1500克(不到四分之三磅)。在后一组中，神经缺陷 在近90%的幸存者中可以观察到：脑性瘫痪的发生率为5%-10%，脑瘫患者的脑瘫发生率为 大约50%的人有认知、行为或注意力。2005年，生命第一年的医疗费用 平均为41,610美元，相比之下，足月婴儿为2830美元，每年的住院总费用为7.4美元 十亿美元。磁共振成像越来越多地被用来观察这些婴儿的大脑 以了解为什么这么多人有这些发育异常。大多数研究都集中在 对大脑半球白质的损伤，但最近的研究发现 小脑发育异常，小脑是大脑的后部。小脑有 传统上与运动强度和协调性联系在一起，最近被牵连 在认知功能上。因此，早产不良后果的一个组成部分可能与 小脑发育异常。这项研究建议使用最先进的磁共振 小脑发育过程中代谢和微结构的评价技术 将早产儿的发育与潜在的可治疗疾病联系起来 婴儿的其他器官系统与两种常见的早产儿的脑部状况 新生儿：脑室出血，脑白质损伤。这是假定的 脑室系统和小脑周围蛛网膜下腔的出血可以防止 小脑从覆盖它的组织接收重要信号，而对大脑造成损伤 白质可能会干扰发送到小脑的信号，从而导致小脑损伤。 早产儿的大脑。查明致病因素可能会使这些因素得以避免或 更积极的治疗，最终导致较少的小脑损伤和改善临床结果。 项目/绩效网站(S)(如果需要额外空间，请使用项目/绩效网站格式页面) 项目/绩效站点主要位置 组织名称：加州大学旧金山分校 邓斯：608379298 街1：巴纳苏斯大道505号街2： 城市：旧金山州：加州 省：国家：美国邮政编码：94143-0628San Francisco 县： 项目/表演场地国会地区： 其他项目/绩效站点位置 组织名称： 邓斯： 第一街：第二街： 城市：州： 省：国家：邮政编码：县： 项目/表演场地国会地区：

PROJECT SUMMARY: Between 13 and 16% of children born in the united States are born prematurely, with nearly 2% of these weighing less than 1500 g (less than three-quarters of a pound). In this latter group, neurological deficits are observed in nearly 90% of those who survive: cerebral palsy is found in 5-10% and deficits in cognition, behavior, or attention is found in about 50%. In 2005, medical costs during the first year of life averaged $41,610, compared to $2830 for a full term baby, for total annual hospital charges of $7.4 billion. Magnetic resonance imaging is being used increasingly to look at the brains of these babies in order to understand why so many have these developmental abnormalities. Most studies have focused upon injury to the white matter of the cerebral hemispheres, but recent studies have discovered frequent abnormalities of development of the cerebellum, a more posterior part of the brain. The cerebellum has traditionally been associated with motor tone and coordination, and more recently has been implicated in cognitive function. As a result, a component of the adverse outcome from prematurity may relate to abnormal cerebellar development. This study proposes to use state-of-the-art magnetic resonance techniques to assess the metabolism and microstructure of the cerebellum during development in prematurely born neonates and to correlate that development with potentially treatable conditions in other organ systems of the baby and with two common conditions of the brain in prematurely born neonates: hemorrhage into the cerebral ventricles, and injury of the cerebral white matter. It is postulated that hemorrhage into the ventricular system and subarachnoid spaces around the cerebellum prevents the cerebellum from receiving important signals from the tissues that cover it, while injury to the cerebral white matter might interfere with signals sent to the cerebellum, thus contributing to cerebellar injury of the premature brain. Identification of the causative factors might allow those factors to be avoided or treated more aggressively, ultimately resulting in less cerebellar damage and improved clinical outcome. PROJECT/PERFORMANCE SITE (S) (if additional space is needed, use Project/Performance Site Format Page) Project/Performance Site Primary Location Organizational Name: University of California at San Francisco DUNS: 608379298 Street 1: 505 Parnassus Avenue Street 2: City: San Francisco State: CA Province: Country: USA Zip/Postal Code: 94143-0628 San Francisco County: Project/Performance Site Congressional Districts: Additional Project/Performance Site Location Organizational Name: DUNS: Street 1: Street 2: City: State: Province: Country: Zip/Postal Code: County: Project/Performance Site Congressional Districts: