Functional dyspepsia: Characterisation of the immunopathology and testing a novel therapeutic strategy.

消化不良，不明原因的胃不适和疼痛，是一个常见且昂贵的问题；几乎没有有效的治疗方法，原因也不清楚。我们发现，消化不良患者小肠顶部的一种免疫细胞--嗜酸性粒细胞的数量增加。这项研究将探索导致嗜酸性粒细胞增加的机制，然后测试一种治疗方法的有效性，以抑制这种过度活跃的免疫反应，这可能会迅速改变临床实践。

Dyspepsia, unexplained stomach discomfort and pain, is a common and costly problem; few effective treatments exist and the causes are unknown. We have found that the numbers of a type of immune cell, the eosinophil, are increased in the top of the small bowel in patients with dyspepsia. This study will explore the mechanisms that lead to increased eosinophils and then test the effectiveness of a treatment to suppress this overactive immune response which could rapidly change clinical practice.