Scimagix Web-Based Scientific Image Management System

描述（由申请人提供）：本提案为福赛斯研究所申请资金，用于建立一个共享的、基于网络的科学图像管理系统（SIMS），该系统使用Scimagix， Inc. （http://www.scimagix.com）的商用软件。申请资金的项目包括：(1)Scimagix SIMS应用软件，(2)SIMS所需的应用服务器硬件，(3)用于存储映像的磁盘阵列，(4)作为SIMS后端的Oracle 9i数据库软件应用，(5)Oracle 9i运行所需的服务器硬件，(6)用于在服务器硬件故障时备份和恢复映像和数据的磁带备份系统。福赛斯是国际公认的世界上最重要的独立研究机构，专注于口腔和颅面生物学。为了保持高水平的研究成果，研究人员必须随时获得尖端仪器和适当的软件工具。目前，Forsyth调查员每周生成的高分辨率图像数据超过10GB，并且没有有效的方法来存储、搜索和检索这些图像。几乎所有的映像都存储在可移动媒体上，主要是CDROM和Zip软盘。有些分散在硬盘驱动器或Forsyth网络上的文件系统中。Forsyth的数字成像源包括但不限于EM和TEM，共聚焦激光扫描显微镜（CLSM），激光捕获显微解剖显微镜，原子力显微镜，显微放射照相，通过光学显微镜进行的数字静止和视频成像，紫外线和荧光显微镜，数字放射照相和口内数字摄影。福赛斯的大多数实验室都配备了至少一台数码显微镜，要么是独立的，要么是连接到计算机工作站的。Scimagix的SIMS将提供一种用户友好的方式，方便存储、搜索和检索用于Forsyth的研究和出版的图像，并将立即使Forsyth的全部项目中的17个受益。这些项目可以根据研究中使用的成像技术类型分为几个大类：(1)使用CLSM生成的图像研究口腔生物膜的形成，生物膜与上皮细胞的相互作用以及对生物膜的免疫反应；(2)利用原位杂交和CLSM技术定位基因表达；(3)利用数字芯片高通量筛选口腔细菌基因的全局表达；(4)利用荧光成像系统（STORM 840）研究特异性基因和蛋白的表达以及CLSM的光学切片能力；(5)利用CLSM和微CT技术定位破骨细胞基因表达、蛋白精化和分子相互作用，研究骨吸收中的基因调控机制。福赛斯研究所保证提供：(1)计算和网络技术办公室的住房，用于支持SIMS应用所需的额外服务器硬件；(2)安装和最终用户培训费用；(3)软件实施过程中的现场咨询；(4) Forsyth数据库管理员Oracle培训；(5) SIMS应用程序和Oracle 9i数据库软件的年度软件维护；(6)永久的内部支持。

DESCRIPTION (provided by applicant): This proposal requests funds for The Forsyth Institute to establish a shared, web-based scientific image management system (SIMS) using commercially available software from Scimagix, Inc. (http://www.scimagix.com). Funds are being requested for the: (1) Scimagix SIMS application software, (2) application server hardware required for SIMS, (3) the disk array for image storage, (4) Oracle 9i database software application which serves as the backend to SIMS, (5) server hardware required for operation of Oracle 9i, and (6) tape backup system for backup and recovery of images and data in the event of server hardware failure. Forsyth is recognized internationally as the world's foremost independent research institute focusing on oral and craniofacial biology. In order to maintain high standards of achievement in research, cutting edge instrumentation and appropriate software tools must be readily available to its investigators. Currently, Forsyth investigators generate more than 10GB of high resolution image data/week and there is no effective means of storing, searching and retrieving these images. Nearly all images are stored on removable media, primarily CDROM and Zip floppies. Some are scattered throughout the file systems on hard-drives or the Forsyth network. Digital imaging sources at Forsyth include, but are not limited to, EM and TEM, confocal laser scanning microscopy (CLSM), laser capture microdissection microscopy, atomic force microscopy, microradiography, digital still and video imaging through light microscopes, UV and fluorescent microscopy, digital radiography and intraoral digital photography. Most of the laboratories at Forsyth are equipped with at least 1 digital microscope, either stand-alone or attached to a computer workstation. Scimagix's SIMS will provide a user-friendly means to facilitate the storage, search and retrieval of images for use in research and publication at Forsyth and will immediately benefit 17 of the total projects at Forsyth. These projects can be grouped into a number of broad categories based on the kinds of imaging technologies utilized in the research: (1) the study of oral biofilm formation, the interaction of biofilm with epithelial cells, and the immune response to biofilm using images generated from the CLSM; (2) mapping gene expression using in situ hybridization and CLSM (3) global expression of genes in oral bacteria from high throughput screening of digital microarrays; (4) the study of specific gene and protein expressions using a fluorescent imaging system (STORM 840) and the optical sectioning capabilities of the CLSM; and (5) mechanisms of gene regulation in bone resorption by localizing gene expression, protein elaboration and molecular interactions in osteoclasts using CLSM and micro CT. The Forsyth Institute guarantees to provide for: (1) housing in the Office of Computing & Network Technology for the additional server hardware needed to support the SIMS application; (2) installation and end-user training costs; (3) onsite consulting during software implementation; (4) Oracle training for Forsyth's database administrator; (5) annual software maintenance for both the SIMS application and the Oracle 9i database software and (6) permanent in house support.