Understanding the cellular and humoral immune response to viral vectors

病毒载体能够安全有效地将基因传递到靶组织和器官中，这改变了医学、生物医学研究和疫苗开发。虽然使用病毒载体的遗传性视网膜变性的基因疗法已经开创了其临床应用，但载体诱导的炎症被认为是基因递送至中枢神经系统（CNS）的功效和持久性的关键限制因素。这个ABViP DPhil项目将专注于了解病毒载体的细胞和体液免疫反应，旨在创造更有效的病毒产品。它将在患者和动物模型中探索病毒载体诱导的免疫激活途径，包括探索细胞因子，分子触发因子和免疫检查点的作用。该项目将提供机会，以获得最先进的病毒载体生物学，分子生物学，蛋白质组学/转录组学和体内实验技术在临床神经科学的Nuffield部门（牛津大学），并与UCL和牛津生物医学合作。

Viral vectors enable safe and efficient delivery of genes into target tissues and organs, which have transformed medicine, biomedical research and vaccine development. While gene therapies for inherited retinal degenerations using viral vectors have pioneered their clinical application, vector-induced inflammation is recognised as a key limiting factor for the efficacy and durability of gene delivery to the central nervous system (CNS). This ABViP DPhil project will focus on understanding the cellular and humoral immune responses to viral vectors with the aim of creating more effective viral products. It will explore viral vector-induced immune activation pathways in patients and animal models, including probing the roles of cytokines, molecular triggers and immune checkpoints. The project will provide opportunities to acquire state-of-the-art training in viral vector biology, molecular biology, proteomics/transcriptomics and in vivo experimental techniques at the Nuffield Department of Clinical Neurosciences (University of Oxford) and in collaboration with UCL and Oxford Biomedica.