The Biostatistics and Data Management Core

生物统计和数据管理核心(生物统计和数据管理核心)将作为调查人员的集中资源 建议的SCCOR急性主动脉夹层项目拨款，以确保分散的元素 程序保持同步，并根据需要提供数据库管理和生物统计服务。 核心将成为数据采集和管理、设计临床和基础数据的集中资源 科学实验、开发创新的统计方法、统计分析和出版 SCCOR项目产生的研究成果。公契的具体目标是： 1.协助筹划和研究拨款项目的设计，包括样本数目和权力 计算和数据分析计划。 2.促进SCCOR项目之间的数据收集、录入、质量控制和数据集成 包括基础科学、临床前、临床和流行病学项目。 3.开发一个安全、基于网络的数据库管理系统，用于跟踪、分发和集中 遗传、社会人口学、实验室、生物标志物、影像和临床数据的储存库。 4.提供研究监测，及时向IRBs报告不良事件，以确保患者安全 和数据监测委员会。 5.进行统计分析，包括描述性分析、假设检验、估计和 统计模型的构建。 6.发展和应用适合于急性主动脉夹层研究的创新统计方法。 7.编写统计报告并合作出版科学成果。

The Biostatistics and Data Management Core (BDMC) will serve as a centralized resource to the investigators of the proposed SCCOR Acute Aortic Dissection Project grant to insure that the dispersed elements of program remain synchronized, and to providing database management and biostatistical services as needed. The core will seve as a centralized resource for data acquisition and management, designing clinical and basic science experiments, developing innovative statistical methodology, statistical analysis, and publishing research results generated by the SCCOR projects. The specific aims of the BDMC are: 1. To assist in the planning and study design of the grant projects, including sample size and power calculations and data analysis plans. 2. To facilitate data collection, entry, quality control, and data integration among SCCOR projects which include basic science, pre-clinical, clinical and epidemiologic projects. 3. To develop a secure, web-based database management system for tracking, distribution and central repository of genetic, socio-demographic, laboratory, biomarker, imaging and clinical data. 4. To provide study monitoring that would ensure patient safety by timely reporting of adverse events to IRBs and the Data Monitoring Committee. 5. To conduct statistical analyses including descriptive analyses, hypothesis testing, estimation, and construction of statistical models. 6. To develop and apply innovative statistical methods pertienent to acute aortic dissection studies. 7. To generate statsitical reports and to collaborate in publication of scientific results.