Biostatistics Shared Resource

生物统计共享资源

• 批准号: 10478024
• 负责人: CHUL W AHN
• 金额: $ 23.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478024
• 关键词: Award; Basic Science; Biological Markers; Biometry; Biostatistics Shared Resource; Biotechnology; Cancer Center Support Grant; Cancer Research Project; Clinical; Clinical Oncology; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Complex; Comprehensive Cancer Center; Computer Hardware; Computer software; Consultations; Data; Data Analyses; Data Science; Databases; Development; Doctor of Philosophy; Education; Educational workshop; Electronic Health Record; Ensure; Extramural Activities; Faculty; Funding; Genetic; Goals; Grant; International; Investigation; Journals; Malignant Neoplasms; Manuscripts; Medical center; Methodology; Methods; Monitor; NCI Center for Cancer Research; Nature; Oncology; Peer Review; Play; Population; Population Sciences; Population Study; Protocols documentation; Publications; Publishing; Quality Control; Reproducibility; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Safety; Screening for cancer; Services; Statistical Methods; Therapeutic Agents; Therapeutic procedure; Training and Education; Translational Research; Work; Writing; anticancer research; base; cancer clinical trial; data management; data quality; design; experimental study; genetic epidemiology; innovation; insight; investigator-initiated trial; lectures; member; method development; multidimensional data; novel therapeutics; population based; programs; quality assurance; randomized trial; recruit; statistical service; success; tool; translational pipeline; trial design

The Biostatistics Shared Resource (BSR) is a centralized resource that provides state-of-the-art biostatistical support for investigators conducting cancer research at Simmons Comprehensive Cancer Center (SCCC). Advances in biotechnologies and computing hardware/software have greatly increased the need for sophisticated statistical methodologies, and biostatistics is an essential component in ensuring high-quality cancer research, particularly in clinical and translational research. BSR biostatisticians play important integrated roles in each of the SCCC Research Programs. The formats of these productive collaborations include pre- award project and clinical trial development as well as post-award, project-oriented statistical services. SCCC research covers the full spectrum of the translational pipeline, ranging from basic science experiments, biomarker studies, investigator-initiated clinical trials of novel therapeutic agents and procedures, to population- based studies. The BSR faculty also offers workshops, office consultations, seminars, and courses on study design, analysis methods, and software implementation to fellows, research staff, and faculty. The BSR is led by Chul Ahn, PhD, a distinguished biostatistician with a national and international reputation for his statistical designs and analyses of cancer research and cancer clinical trials. BSR biostatisticians are also key contributing members of SCCC’s Protocol Review and Monitoring Committee (PRMC) and Data and Safety Monitoring Committee (DSMC), providing valuable independent statistical input. The BSR currently consists of efforts from five faculty biostatisticians and three analysts, providing all levels of biostatistics support. The services of the BSR were utilized by 178 members across five SCCC research programs from 2014-2019 and provided key data and insights to support the success of 68 new cancer-related extramurally funded grants, 96 cancer clinical trials, and 267 peer-reviewed publications, including work published in top tier journals such as JAMA, Journal of Clinical Oncology, JAMA Oncology, Lancet Oncology, Cancer Discovery, Cancer, Nature Genetics, and Nature. Goals for the next funding period include recruiting additional biostatisticians to strengthen expertise in adaptive trial design.

生物统计共享资源（BSR）是一个集中的资源，提供最先进的生物统计 为西蒙斯综合癌症中心（SCCC）进行癌症研究的研究人员提供支持。 生物技术和计算机硬件/软件的进步大大增加了对 先进的统计方法，生物统计是确保高质量的 癌症研究，特别是临床和转化研究。BSR生物统计学家发挥重要的综合作用 在每个SCCC研究项目中的角色。这些富有成效的合作形式包括： 获奖项目和临床试验开发以及获奖后面向项目的统计服务。SCCC 研究涵盖了翻译管道的全部范围，从基础科学实验， 生物标志物研究，药物启动的新型治疗药物和程序的临床试验， 基于研究。BSR教师还提供研讨会，办公室咨询，研讨会和学习课程 设计，分析方法和软件实现研究员，研究人员和教师。BSR是由 作者：Chul Ahn博士，一位杰出的生物统计学家，他的统计学在国内和国际上享有盛誉。 癌症研究和癌症临床试验的设计和分析。BSR生物统计学家也是关键贡献者 SCCC方案审查和监测委员会（PRMC）以及数据和安全性监测委员会的成员 委员会（DSMC），提供宝贵的独立统计投入。BSR目前由以下方面的努力组成： 五名生物统计学家和三名分析师，提供各级生物统计学支持。的服务 从2014年到2019年，178名成员在五个SCCC研究项目中使用了BSR，并提供了关键的 数据和见解，以支持成功的68个新的癌症相关的壁外资助赠款，96癌症临床 试验，以及267篇同行评议的出版物，包括在顶级期刊上发表的工作，如JAMA，Journal 临床肿瘤学，JAMA肿瘤学，柳叶刀肿瘤学，癌症发现，癌症，自然遗传学，和 自然下一个资助期的目标包括招聘更多的生物统计学家，以加强以下方面的专业知识： 适应性试验设计