Biostatistics Shared Resource

生物统计共享资源

• 批准号: 10170623
• 负责人: CHUL W AHN
• 金额: $ 23.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10170623
• 关键词: Award; Basic Science; Biological Markers; Biometry; Biostatistics Shared Resource; Biotechnology; Cancer Center Support Grant; Cancer Research Project; Clinical; Clinical Oncology; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Complex; Comprehensive Cancer Center; Computer software; Consultations; Data; Data Analyses; Data Science; Databases; Development; Doctor of Philosophy; Education; Educational workshop; Electronic Health Record; Ensure; Extramural Activities; Faculty; Funding; Genetic; Goals; Grant; International; Investigation; Journals; Malignant Neoplasms; Manuscripts; Medical center; Methodology; Methods; Monitor; NCI Center for Cancer Research; Nature; Oncology; Peer Review; Play; Population; Population Sciences; Population Study; Protocols documentation; Publications; Publishing; Quality Control; Reproducibility; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Safety; Screening for cancer; Services; Statistical Methods; Therapeutic Agents; Therapeutic procedure; Training and Education; Translational Research; Work; Writing; anticancer research; base; cancer clinical trial; data management; data quality; design; experimental study; genetic epidemiology; innovation; insight; investigator-initiated trial; lectures; member; method development; multidimensional data; novel therapeutics; population based; programs; quality assurance; randomized trial; recruit; statistical service; success; tool; translational pipeline; trial design

The Biostatistics Shared Resource (BSR) is a centralized resource that provides state-of-the-art biostatistical support for investigators conducting cancer research at Simmons Comprehensive Cancer Center (SCCC). Advances in biotechnologies and computing hardware/software have greatly increased the need for sophisticated statistical methodologies, and biostatistics is an essential component in ensuring high-quality cancer research, particularly in clinical and translational research. BSR biostatisticians play important integrated roles in each of the SCCC Research Programs. The formats of these productive collaborations include pre- award project and clinical trial development as well as post-award, project-oriented statistical services. SCCC research covers the full spectrum of the translational pipeline, ranging from basic science experiments, biomarker studies, investigator-initiated clinical trials of novel therapeutic agents and procedures, to population- based studies. The BSR faculty also offers workshops, office consultations, seminars, and courses on study design, analysis methods, and software implementation to fellows, research staff, and faculty. The BSR is led by Chul Ahn, PhD, a distinguished biostatistician with a national and international reputation for his statistical designs and analyses of cancer research and cancer clinical trials. BSR biostatisticians are also key contributing members of SCCC’s Protocol Review and Monitoring Committee (PRMC) and Data and Safety Monitoring Committee (DSMC), providing valuable independent statistical input. The BSR currently consists of efforts from five faculty biostatisticians and three analysts, providing all levels of biostatistics support. The services of the BSR were utilized by 178 members across five SCCC research programs from 2014-2019 and provided key data and insights to support the success of 68 new cancer-related extramurally funded grants, 96 cancer clinical trials, and 267 peer-reviewed publications, including work published in top tier journals such as JAMA, Journal of Clinical Oncology, JAMA Oncology, Lancet Oncology, Cancer Discovery, Cancer, Nature Genetics, and Nature. Goals for the next funding period include recruiting additional biostatisticians to strengthen expertise in adaptive trial design.

生物统计共享资源 (BSR) 是一种集中式资源，可提供最先进的生物统计数据 为西蒙斯综合癌症中心 (SCCC) 进行癌症研究的研究人员提供支持。 生物技术和计算硬件/软件的进步大大增加了对 复杂的统计方法和生物统计学是确保高质量的重要组成部分 癌症研究，特别是临床和转化研究。 BSR 生物统计学家发挥着重要的综合作用 在每个 SCCC 研究项目中的角色。这些富有成效的合作的形式包括预 奖励项目和临床试验开发以及奖励后、面向项目的统计服务。新加坡华人文化中心 研究涵盖了转化管道的各个方面，从基础科学实验， 生物标志物研究、研究者发起的新型治疗药物和程序的临床试验 基础研究。 BSR 教师还提供研讨会、办公室咨询、研讨会和学习课程 向研究员、研究人员和教师提供设计、分析方法和软件实施。 BSR 被引导 作者：Chul Ahn 博士，一位杰出的生物统计学家，因其统计学而在国内外享有盛誉 癌症研究和癌症临床试验的设计和分析。 BSR 生物统计学家也是关键贡献者 SCCC 协议审查和监测委员会 (PRMC) 以及数据和安全监测委员会成员 委员会 (DSMC)，提供宝贵的独立统计输入。 BSR 目前包括以下方面的努力： 五名生物统计学家和三名分析师，提供各级生物统计学支持。的服务 2014 年至 2019 年，BSR 被 SCCC 五个研究项目的 178 名成员使用，并提供了关键 数据和见解支持 68 项新的与癌症相关的外部资助、96 项癌症临床的成功 试验以及 267 篇同行评审出版物，包括发表在 JAMA、Journal 等顶级期刊上的作品 临床肿瘤学、JAMA 肿瘤学、柳叶刀肿瘤学、癌症发现、癌症、自然遗传学和 自然。下一个资助期的目标包括招募更多生物统计学家以加强以下领域的专业知识： 适应性试验设计。