Organic Synthesis Reagents on Transition Metals

描述（由申请人提供）：复杂分子中碳-碳键的合成对于新药物的构建至关重要。在过去的几年中，烯烃复分解已成为一种新的通用方法来构建这类化合物。实现这一转变的关键是获得活性、高效和选择性的催化剂。在过去的几年里，已经开发出了一系列催化剂，这些催化剂在广泛的无保护官能团存在下显示出高活性。进一步的应用将需要具有对映和立体选择性的催化剂，并能在高度功能化的烯烃上进行复分解。在上一个授权期间，在开发指导配体设计的模型方面取得了进展。在下一个授权期内，该模型将用于构建新的配体体系，用于对映选择性交叉复分解，用于交叉复分解的立体选择性（控制形成的双键的E:Z比），并提高立体阻碍烯烃的反应性。将制备出多种新型n -杂环羰基配体，这些配体不仅在烯烃选择性分解催化剂的制备中具有应用价值，而且在催化剂设计中具有广泛的应用价值。这类催化剂的成功构建将为生物活性分子的构建开辟有效的新途径。

DESCRIPTION (provided by applicant): The synthesis of carbon-carbon bonds in complex molecules is essential for the construction of new pharmaceutical agents. Over the past several years, olefin metathesis has become a new general method for the construction of such compounds. Key to this transformation is the availability of catalysts that are active, efficient and selective. Over the past several years, a family of catalysts has been developed that shows high activity in the presence of a wide array of unprotected functional groups. Further applications will require catalysts that are enantio and stereoselective and will carry out metathesis on highly functionalized olefins. During the last granting period, progress was made in the development of a model to direct ligand design. During the next granting period, this model will be used to construct new ligand systems for enantioselective cross metathesis, for the stereoselective (control the E:Z ratio of the double bonds formed) in cross metathesis and increase the reactivity of sterically hindered olefins. A variety of new N-heterocyclic carbene ligands will be prepared that will not only have applications in the preparation of selective olefin metathesis catalysts but will be of general use in catalyst design. Successful construction of such catalysts will open efficient new routes to the construction of bioactive molecules.