Stereoselective organo-metal catalysis for the synthesis of value-added products

化学家发明新转变的能力是我们现代社会的核心，因为新的化学方法可以提高精确度和选择性，使材料、药品、农用化学品和精细化学品的制备更有效。催化是一种强大的工具，可以设计新的反应，使现有的反应更具选择性，从而有助于更可持续地利用自然资源。在此背景下，本博士项目以新颖的方式融合了有机和过渡金属催化的元素，为不饱和原料底物的立体选择反应和面向医学相关支架的可持续合成开辟了新的途径。该博士生将设计和制备新型有机催化剂，能够通过非共价相互作用与普通金属卤化物（预）催化剂相结合。然后，这些二元催化体系将用于各种各样的反应中，以实现从最低功能化，电子无偏的底物开始的更高速率，不同寻常的区域和立体选择性和/或前所未有的对映体控制水平。

The ability of chemists to invent new transformations is at heart of our modern society, as novel chemical methods to forge bonds with increased precision and selectivity enable more efficient preparation of materials, medicines, agrochemicals and fine chemicals. Catalysis is a powerful tool to devise new reactions and render the existing ones more selective, thus contributing to a more sustainable use of natural resources. In this context, the present PhD project merges in original ways elements taken from both organo- and transition-metal catalysis, to open new paths for stereoselective reactions of unsaturated feedstock substrates and for sustainable synthesis oriented to medicinally relevant scaffolds.The PhD student will design and prepare novel organocatalysts capable of engaging with common metal halide (pre)catalysts via non-covalent interactions. These binary catalytic systems will then be employed in a large variety of reactions to achieve increased rate, unusual regio- and stereoselectivity and/or unprecedented levels of enantiocontrol starting from minimally functionalised, electronically unbiased substrates.