Psychosocial Influences on Systemic Lupus

描述（由申请人提供）： 申请人的长期目标，卡罗尔M。Greco博士，成为风湿性疾病的独立临床研究者，专注于系统性红斑狼疮（SLE）的生物心理社会影响。候选人是家庭医学，麻醉学的研究助理教授。和康复科学与技术，匹兹堡大学医学院，和一个持牌临床心理学家。Greco博士的培训目标是扩大她在风湿性疾病和生物统计学的生物医学和临床方面的知识基础，并加强她在心血管行为医学，心理生理学评估和心理神经免疫学方面的技能。导师Susan Manzi，医学博士，公共卫生硕士，Karen马修斯，博士，安德鲁·鲍姆博士在匹兹堡大学拥有完善的研究和培训中心，包括新成立的狼疮卓越中心，匹兹堡身心中心，以及心血管行为医学和肿瘤学行为医学课程。将实施医学，流行病学，心理学和生物统计学课程，研讨会，讲座和培训计划，以完成候选人的培训目标。Greco将定期与她的导师和合作者会面，以成功地将开发的技能应用于正在进行的和新启动的研究项目。她提出的研究项目是Manzi博士和Joseph Ahearn博士（合作者）两个资助的父项目的产物，旨在调查心理社会因素在SLE疾病活动性发作和SLE心血管疾病中的作用。具体而言，Greco博士打算确定心理社会因素（1）是否影响SLE疾病活动的波动。（2）SLE亚临床和临床血管病变的dsk增加。结果有望导致急性应激源对SLE心血管功能和免疫系统参数的影响的研究，并最终发展行为干预措施，以改善健康和减少SLE症状。

DESCRIPTION (provided by applicant): The long-term objective of the applicant, Carol M. Greco, Ph.D., is to become an independent clinical investigator in rheumatic disease, with a specialized focus on biopsychosocial influences in systemic lupus erythematosus (SLE). The candidate is a research assistant professor of Family Medicine, Anesthesiology. and Rehabilitation Science and Technology, University of Pittsburgh School of Medicine, and a licensed clinical psychologist. Dr. Greco's training objectives are to expand her knowledge base in biomedical and clinical aspects of rheumatologic diseases and biostatistics, and strengthen her skills in cardiovascular behavioral medicine, psychophysiologic assessment, and psychoneuroimmunology. Mentors Susan Manzi, MD, MPH, Karen Matthews, Ph.D., and Andrew Baum, Ph.D. have well-established research and training centers at the University of Pittsburgh, including the newly established Lupus Center of Excellence, the Pittsburgh Mind-Body Center, and programs in Cardiovascular Behavioral Medicine and Behavioral Medicine in Oncology. A program of medical, epidemiology, psychology and biostatistics coursework, and seminars, lectures, and precepted training will be implemented to accomplish the candidate's training objectives. Dr. Greco will meet regularly with her mentors and collaborators to successfully apply the developed skills in ongoing and newly initiated research programs. Her proposed research project is an outgrowth of two funded parent projects of Dr. Manzi and Dr. Joseph Ahearn (collaborator), and is aimed at investigating the role of psychosocial factors in SLE disease activity flares and in cardiovascular disease in SLE. Specifically, Dr. Greco intends to determine whether psychosocial factors (1) influence fluctuation in SLE disease activity. and (2) increase dsk of subclinical and clinical vascular disease in SLE. Results are expected to lead to studies of the impact of acute stressors on cardiovascular function and immune system parameters in SLE, and ultimately to the development of behavioral interventions to improve health and reduce SLE symptoms.