Reducing Depressive Symptoms in Systemic Lupus Erythematosus

减少系统性红斑狼疮的抑郁症状

• 批准号: 8264379
• 负责人: CAROL MARIE GRECO
• 金额: $ 32.4万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264379
• 关键词: Accounting; Address; Adult; Affect; African American; Aftercare; Anguish; Antigens; Area; Arthralgia; Attention; Attenuated; Autoimmune Diseases; Behavior; Behavior Therapy; Binding; Biological Markers; Biomedical Research; Caucasians; Caucasoid Race; Cells; Chronic; Chronic Disease; Cognitive Therapy; Complement Activation; Complex; Control Groups; Counseling; Depressive disorder; Disease; Distress; Dose; Educational Intervention; Endogenous depression; Epidemiologic Studies; Equipment and supply inventories; Etiology; Evaluation; Fatigue; Female; Flare; Future; General Population; Great Britain; Guided imagery; Health; Healthcare; Hospitalization; Immune; Immune response; Incidence; Inflammation; Inflammatory; Intervention; Investigation; Lead; Lupus; Major Depressive Disorder; Measures; Mediator of activation protein; Medical; Mental Depression; Mental Health; Mind-Body Intervention; Mind-Body Method; Musculoskeletal Diseases; Myalgia; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Organ; Outcome; Outcome Measure; Pain; Participant; Patients; Pharmaceutical Preparations; Pilot Projects; Population; Publishing; Randomized; Randomized Controlled Trials; Relapse; Relaxation; Research; Rheumatism; Sampling; Self Care; Self Efficacy; Self Management; Serum; Severities; Site; Socioeconomic Status; Stress; Symptoms; Systemic Lupus Erythematosus; Testing; Therapeutic; Time; Training; Training Programs; Translating; Woman; Work; abstracting; activation product; biopsychosocial; body-mind; burden of illness; complement C4d; coping; depressive symptoms; design; disability; disability-adjusted life years; emotion regulation; follow-up; health related quality of life; immune activation; immune function; improved; indexing; innovation; inventory of depressive symptomatology; low socioeconomic status; mindfulness; novel; novel strategies; physical conditioning; primary outcome; psychologic; psychological distress; single episode major depressive disorder; skills; skills training; skin disorder; success; therapy design

Abstract Systemic lupus erythematosus (SLE) is a chronic, multisystemic inflammatory disease that is frequently associated with significant psychological suffering. Building upon our team's strengths in lupus biomedical research and behavioral interventions, we propose to study a non-pharmacologic intervention to improve mental and physical health of patients with SLE and co-morbid depression. In this project, entitled, Reducing Depressive Symptoms in SLE, we will investigate the efficacy of an innovative non-pharmacologic intervention, Mind-Body Skills Training (MBST) for improving mental and physical health outcomes in SLE in a randomized controlled trial (RCT). MBST is a novel approach that combines cognitive-behavioral therapy methods, mind-body relaxation skills, and mindfulness components, each of which is beneficial for reducing pain and/or distress in other inflammatory conditions. We will assign 150 SLE patients with depressive disorder or subsyndromal depression to MBST or to a supportive counseling control condition. The primary specific aims of the project are to evaluate the effects of the 8-session MBST program on 1) mental health (depression) and 2) physical health (pain, fatigue, and health-related quality of life). Additionally we will explore the effects of the MBST intervention on 1) novel SLE biomarkers of inflammation and immune function: cell-bound complement activation products, developed at our site, 2) measures of SLE disease activity, and we will explore 3) potential treatment modifiers and mediators: baseline pain and socioeconomic status, and self-efficacy and perceived stress. We will evaluate health outcomes after the interventions and at 6- and 12-months follow-up. SLE is one of the most complex autoimmune diseases, with one of the highest rates of depression. The MBST intervention has strong potential for addressing the unique physical manifestations and mental suffering in this patient group, and may have broad impact on distressed patients with other debilitating chronic diseases.

抽象的 系统性红斑狼疮 (SLE) 是一种慢性、多系统炎症性疾病，经常发生 与严重的心理痛苦有关。建立我们团队在狼疮生物医学领域的优势 研究和行为干预，我们建议研究非药物干预措施以改善 SLE 和共病抑郁症患者的心理和身体健康。 在这个题为“减少 SLE 抑郁症状”的项目中，我们将研究一种药物的功效 创新的非药物干预，身心技能训练（MBST），以改善精神和 随机对照试验 (RCT) 中 SLE 的身体健康结果。 MBST 是一种新颖的方法 结合了认知行为治疗方法、身心放松技巧和正念成分， 其中每一种都有益于减轻其他炎症条件下的疼痛和/或痛苦。我们将分配 150 名患有抑郁症或亚综合征抑郁症的 SLE 患者接受 MBST 或支持性咨询 控制条件。该项目的主要具体目标是评估 8 次 MBST 的效果 1) 心理健康（抑郁）和 2) 身体健康（疼痛、疲劳和健康相关质量）的计划 生活）。此外，我们将探讨 MBST 干预对 1) 新型 SLE 生物标志物的影响 炎症和免疫功能：我们网站开发的细胞结合补体激活产品，2) SLE 疾病活动性的衡量标准，我们将探讨 3) 潜在的治疗调节因素和调节因素： 基线疼痛和社会经济地位，以及自我效能和感知压力。我们将评估健康状况 干预后以及 6 个月和 12 个月随访时的结果。 系统性红斑狼疮是最复杂的自身免疫性疾病之一，也是抑郁症发病率最高的疾病之一。 MBST 干预对于解决该地区独特的身体表现和精神痛苦具有强大的潜力 患者群体，并可能对患有其他使人衰弱的慢性疾病的痛苦患者产生广泛影响。