Health and Literacy in Child and Adult Assessment(RMI)

描述（由申请人提供）：“儿童和成人健康和读写能力评估”是北卡罗来纳大学教堂山分校及其合作伙伴提出的成为PROMIS主要研究站点的提案，解决了在临床研究中使用计算机自适应测试（CAT）来衡量患者报告的慢性病结果（PROs）的3个重要问题：(1)对8-17岁儿童进行PRO评估（独立项目），(2)在低识字率人群中进行英语和西班牙语的开发和测试项目，以及(3)对变量（例如，功能能力的许多方面或对治疗的依从性）进行严格评估，这些变量最恰当地概念化为二元（例如，妻子-丈夫，父母-孩子）而不是个体。我们独立项目将(1)使用红外热成像来评估8000名儿童4项参数PedsQLTM4.0核心域(身体、情感、社会、学校/认知)和一个asthma-specific域,以这种广泛使用的仪器为起点儿科项银行,(2)开发新项目和收集数据在北卡罗莱纳和德州1060个孩子,利用红外热成像估计项参数,(3)开发和试点测试CAT工具和使用它来调查375名儿童在数控和德克萨斯州。我们的长期目标是开发CAT来评估各种慢性儿童疾病临床研究中的PROs。然而，这一初步数据收集将针对哮喘儿童和健康儿童。

DESCRIPTION (provided by applicant): "Health and Literacy in Child and Adult Assessment," a proposal to become a PROMIS Primary Research Site by The University of North Carolina at Chapel Hill and its partners, addresses 3 important problems in using computer adaptive testing (CAT) to measure patient-reported chronic diseases outcomes (PROs) in clinical research: (1) PRO assessment in children 8-17 years of age (Independent Project), (2) Development and testing items in low literacy populations in English and Spanish, and (3) Rigorous assessment of variables (e.g., many aspects of functional capacity or adherence to treatment) most appropriately conceptualized as dyadic (e.g., wife-husband, parent-child) rather than individual. Our Independent Project will (1) use IRT to evaluate item parameters for the PedsQLTM4.0 in 8,000 children in 4 core domains (physical, emotional, social, school/cognitive) and an asthma-specific domain, taking this widely used instrument as a starting point for a pediatric item bank, (2) develop new items and collect data in 1,060 children in North Carolina and Texas, using IRT to estimate item parameters, (3) develop and pilot test a CAT tool and use it to survey 375 children in NC and Texas. Our long-term objective is to develop CAT to assess PROs in clinical research across a wide range of chronic childhood diseases. However, this initial data collection will be in children with asthma and in healthy children. Our Network Project on literacy proposes developing a methodology for creating and testing PRO items in English and Spanish that function consistently across languages and literacy levels. We will provide leadership for (1) assessing patient literacy, (2) testing item comprehension in low literacy populations, (3) devising a strategy to develop new items that can be understood by people with low literacy, (4) testing all items in diverse samples of English- or Spanish-speaking people to evaluate differential item functioning by language or literacy in our large ethnically diverse patient population representing all literacy levels. Our Network Project on dyadic assessment proposes (1) specifying health variables that are largely interpersonal, (2) identifying existing measures of these and assessing their validity, (3) modifying measures that fail to assess interpersonal processes in a way that captures their interpersonal nature, (4) assisting the Network in collecting data on the modified measures and assessing their validity.