Net Lifetime Health Effects of Alcohol Use & Abuse

描述(由申请人提供)：虽然酒精消费与许多特定疾病实体的风险之间的关联已经进行了非常详细的调查，但在了解酒精消费与整个成年人一生中的健康和疾病的总体关系方面存在严重不足。鉴于酒精既有有害的影响，也有可能有益的影响，重要的是了解其对死亡风险以及一些疾病和健康状况的净影响，这些风险可能与酒精的使用或滥用有积极或消极的关系。我们建议使用在基于人口的弗雷明翰研究中收集的10,000多名受试者27-55年间的数据，将他们成年后大部分时间的饮酒量和模式与生活中最重要的两个方面联系起来：(A)存活率(总死亡率)和(B)认知功能指数。我们还会将饮酒与残疾指数以及其他一些受饮酒影响的疾病和状况联系起来，包括肝病、意外、特定癌症、高血压、冠心病、中风、其他心血管疾病、癫痫、晕厥、跌倒和骨折。弗雷明翰的这项研究的独特之处在于，它能够重复测量饮酒量和饮酒模式，并在基本上整个成年人的一生中(大多数人到老年，超过一半的受试者直到死亡)测量健康和疾病。拟议的研究将在整个后续行动中对每次与每个受试者接触时收集的健康信息进行广泛审查，根据饮酒情况(饮酒量和饮酒模式)对每个受试者进行分类，确定有酒精使用障碍的人，编制关于疾病和死因的完整数据库(目前仅包括心血管疾病和癌症)，然后审查酒精使用和酒精使用障碍与总死亡率(总体和按年龄层次)以及随时间重复评估的认知功能指数的关系。不同饮酒量和饮酒模式的净影响将与不同年龄的结果有关。这项研究将产生一个独特的数据集，并将提供信息，以提高我们对酒精在成年生活中的净影响的了解。

DESCRIPTION (provided by applicant): While the association of alcohol consumption and the risk of many specific disease entities has been investigated in great detail, there are serious deficiencies in knowing the overall relation of alcohol consumption to health and disease throughout the adult lifespan. Given that alcohol has both detrimental and possibly beneficial effects, it is important to know its net effects on the risk of death and of a number of diseases and health conditions that may relate, either positively or inversely, to its use or abuse. We propose to use data collected over 27-55 years among the 10,000+ subjects in the population-based Framingham Study to relate the amount and pattern of alcohol consumption over a large part of their adult lifetime to two of the most important aspects of life: (a) survival (total mortality) and (b) indices of cognitive function. We will also relate alcohol consumption to indices of disability and to a number of other diseases and conditions affected by alcohol intake, including liver disease, accidents, specific cancers, hypertension, coronary disease, stroke, other cardiovascular diseases, seizures, syncope, falls and fractures. The Framingham Study is unique in being able to provide repeated measurements of the amount and pattern of alcohol use and measures of health and disease over what is essentially the entire adult lifespan (until old age for most and until death for more than one half of subjects). The proposed study would carry out an extensive review of health information collected at every encounter with each subject throughout follow up, classify each subject at each encounter according to alcohol consumption (amount and pattern of drinking), identify those with alcohol use disorders, prepare a complete dataset of diseases and causes of death (currently complete only for cardiovascular disease and cancer), and then examine the relation of alcohol use and alcohol use disorders to total mortality (overall and by age strata) and to indices of cognitive function assessed repeatedly over time. The net effects of varying amounts and patterns of drinking would be related to outcomes at different ages. The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life.