Clinical and Basic Neurobiology Nervous System Diseases

描述(由申请人提供)：通过教育基础神经科学家并让他们参与面向疾病的研究，可以最好地减轻神经系统疾病造成的巨大残疾和痛苦负担。为了实现这一目标，我们计划为耶鲁大学所有神经科学研究生开设一门课程，内容是《神经系统疾病的临床和基础神经生物学》，并将其提供给全国各地的其他神经科学培训项目。该课程将是美国国立卫生研究院支持的“跨部门神经科学计划”的一部分(5T32 NS 41228，H.Keshishian Pi)。这门新课程将是目前20门主讲神经退行性疾病的《神经疾病的细胞和分子机制》课程的两倍多。这两门课程将包括44个讲座，涵盖神经学、精神病学和儿童精神病学领域的广泛疾病和障碍。除了讲课和书面教学大纲外，还将为44场讲课制作教程，利用文本、图形、图形、动画和基于网络的互动形式的视频剪辑，让学生回答问题并与图形或动画互动，这些互动会产生即时反馈，并提供表明掌握程度的总分。每堂课的教学大纲教程将包括对疾病的描述、流行病学、遗传学、病例介绍、临床过程、诊断方法、治疗、疾病的动物模型(重点是具体和常见的神经生物学发病机制)，以及对翻译研究的社会和伦理方面的讨论。这门课程将由一个执行咨询委员会领导，由两名共同的首席调查员(一名临床科学家和INP的首席调查员)和来自神经科、精神科和儿童科的其他三名成员共同领导 精神病学和教学人员将来自这三个组织。本课程将通过各种主观和客观的衡量标准进行评估，包括学生在教程中的分数。这门课程将在耶鲁大学以外的地方产生影响，因为讲座的网络直播、教学大纲和教程将通过互联网提供给其他神经科学培训项目。相关性：对基础神经科学研究生进行神经系统疾病的神经生物学教育将培养他们参与以疾病为导向的研究，并导致改进预防和治疗。

DESCRIPTION (provided by applicant): The immense burden of disability and suffering produced by nervous system diseases can best be reduced by educating and involving basic neuroscientists in disease oriented research. To accomplish this we plan to develop a course on the "Clinical and Basic Neurobiology of Diseases of the Nervous System" for all neuroscience graduate students at Yale University and make it available to other neuroscience training programs across the country. The course will be part of the NIH supported "Interdepartmental Neuroscience Program" (INP) (5T32 NS 41228, H. Keshishian PI). The new course will more than double the current 20 lecture course "Cellular and Molecular Mechanisms of Neurologic Disease", which focuses on neurodegenerative diseases. The 2 courses will include a total of 44 lectures covering a wide range of diseases and disorders from the fields of Neurology, Psychiatry and Child Psychiatry. In addition to lectures and a written syllabus, tutorials will be created for each of the 44 lectures utilizing text, graphics, figures, animations and video clips in a web based interactive format to engage students in answering questions and interacting with figures or animations that generate immediate feedback and provide a total score indicating the level of mastery. Each lecture-syllabus-tutorial will include a description of the disease, epidemiology, genetics, case presentations, clinical course, diagnostic methods, treatment, animal models of disease (with a focus on both specific and common neurobiologic mechanisms of pathogenesis), and a discussion of social and ethical aspects of translational research. The course will be directed by an executive-advisory committee led by the 2 co-principle investigators - (a clinician scientist and the principal investigator of the INP) with 3 other members from the Departments of Neurology, Psychiatry and Child Psychiatry and teaching faculty will come from these same 3 organizations. The course will be evaluated with a variety of subjective and objective measures including student scores on the tutorials. The course will have an impact outside Yale University since a webcast of the lecture, the syllabus, and the tutorials will be made available via the internet to other Neuroscience Training Programs. Relevance: The education of basic neuroscience graduate students in the neurobiology of diseases of the nervous system will foster their involvement in disease-oriented research and lead to improved prevention and treatment.